Search for a trial

A biomechanical analysis of the single-leg Roman chair hold and the Nordic hamstring curl

Primary Objective: Investigate wether fascicle length changes of the biceps femoris long head are larger than the typical error during the NHC and the SLRCH.Secondary Objective(s): compare the NHC and the SLRCH on their required hamstring muscle…

Improving the preoperative status of patients undergoing major surgery

To evaluate the feasibility of (1) the use of the Beter Voorbereid* application and the study procedures of a randomized controlled trial (finished in June 2019) and (2) evaluating the effectiveness of the *Beter Voorbereid* application on improved…

Influence of posterior vitreous detachment on retinal detachment after
lens surgery in myopic eyes

The aim of the study is to document the presence and/or post-operative development of PVD and to assess its influence on the incidence of PRD in myopic patients in a time period of three and five years after lens surgery.

A placebo-controlled trial to test the effectiveness of a lighting intervention to reduce or stabilize alcohol use and craving in alcohol dependent patients

The key objective of the current field study is to test the effectiveness of an integrative lighting intervention to support sleep and increase self-control among AUD patients in ambulant care, and, in turn, stabilize and/or reduce alcohol…

Chronotherapy with aspirin for reduction of cardiovascular disease

The aim of this comparative effectiveness research is to determine the effect of intake of aspirin before bedtime in comparison with aspirin on awakening in patients already using aspirin for secondary prevention of CVD. Our primary objective will…

High intensity interval training and skeletal muscle insulin sensitivity: unrevealling health effects and underlying mechanisms

Primary objectives:1.- To test whether a supervised HIIT period (12 weeks) improves the non-oxidative glucose disposal (NOGD) in skeletal muscle of overweight/obese adult subjects. Secondary objectives:1.- To examine whether a supervised HIIT period…

Quality assessment of an integrated care pathway using telemonitoring in patients with chronic heart failure and COPD

To investigate whether an integrated pathway using TM for patients with HF and COPD results in a delayed decline or improved quality of life. Secondary objectives are level of self-management, patient satisfaction, compliance to the program and cost…

The effects of plant sterol and plant stanol ester enriched foods on biopsy proven liver inflammation in NAFLD patients - a proof-of-concept pilot study -

To assess the effect of consuming plant sterol or plant stanol esters (3 grams/day) for 12 months on biopsy proven liver inflammation in NAFLD patients.

Study A: A placebo-controlled crossover study to assess safety of intranasal administration of palivizumab
Study B: Effect of intranasal administration of palivizumab on respiratory syncytial virus-associated infection - a double-blind randomized controlled trial

Study A: Safety of intranasal administration of palivizumab in healthy adultsStudy B: Effect of local administration of palivizumab on prevention of RSV infection

MAASFLEX: A Double-Blind, Randomized, Phase IV, Mechanistic, Placebo-Controlled, Cross-Over, Single-Center Study to Evaluate the Effects of 2 Weeks Dapagliflozin Treatment on Nocturnal Substrate Oxidation, Glucose Metabolism and Muscle Mitochondrial Function in Individuals with Impaired Glucose Homeostasis

The primary objective is to examine the effects of dapagliflozin on nocturnal substrate oxidation in overweight or obese subjects with disrupted glucose homeostasis but without T2D.

A Multicenter, Randomized, Double blind, Vehicle-controlled, Phase 3 Efficacy and Safety Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas (BCCs) in Subjects with Basal Cell Nevus Syndrome

Primary Objective:To assess the number of new BCCs in the 2 arms (Patidegib Topical Gel, 2%, and Vehicle (placebo)) when applied twice daily to the face of subjects with Gorlin Syndrome.Secondary Objective:To assess the safety and tolerability of…

A nurse-led sexual rehabilitation programme for women with gynaecological cancers receiving radiotherapy: a randomized multicentre trial.

In this study, we evaluate the efficacy of a sexual rehabilitation programme in improving the sexual functioning of women who are treated with radiotherapy for gynaecological cancer. The rehabilitation programme is compared to optimal regular care (…

Continious Care trial: The effect of continuous care during childbirth given by a maternity care nurse.

The effect of continuous care during childbirth care compared with current standard care, in which continuous guidance has not yet been achieved.

CHECkUP: Control in the Hospital by Extensive Clinical rules
for Unplanned hospitalisations in elderly Patients.

BACKGROUND/OBJECTIVEHospital readmissions are an indicator of quality of care. To assess whether medication reviews with an extensive set of clinicalrules can help to reduce the number of readmissions, we plan to perform a randomised, multicenter,…

Evaluation of the efficacy of hamstring and calf muscle prevention programs through ultrasound and MRI measures

Objective of the validation study is evaluating the optimal imaging modality, diffusion tensor magnetic resonance imaging (DT-MRI) or ultrasound, for measuring pennation angle and fascicle length, muscle thickness, muscle volume and cross sectional…

Towards OPtimal TIming and Method for promoting sUstained adherence to lifestyle and body weight recommendations in postmenopausal breast cancer survivors: the OPTIMUM-study.

The OPTIMUM-study aims to gain insight into the optimal timing and method for promoting sustained adherence to lifestyle and body weight recommendations in PMBC survivors.The aim of the extra measurement during the second COVID-19 lockdown is to…

Cerebral Micro-emboli Detection
after Cardiac Surgery
(A prospective follow-up study)

To demonstrate the added value of TCD emboli detection in patients after cardiac surgery. To investigate the possibility of an early detection of silent cerebral embolization after a cardiac surgery procedure to identify a subset of patients with an…

AMYPAD Prognostic and Natural History Study (PNHS), an open label, prospective, multicentre, cohort study in individuals without dementia to evaluate the additional value of quantitative amyloid imaging in determining Alzheimer*s Disease (AD) dementia risk

The aim of this study is to evaluate the additional value of quantitative amyloid imaging analysis for modelling and assessing Alzheimer*s Disease (AD) dementia risk in individuals without dementia, compared to a range of existing cognitive, imaging…

Learning to preserve: foreign language training as a cognitive *vaccine* to prevent old-age disorders?

The main objective of this study is to determine whether a bilingual experience in old age affects cognitive flexibility and its neural underpinnings, which could in turn explain health advantages. Secondarily, this study aims to evaluate the effect…

Non-invasive vagus nerve stimulation in acute ischemic stroke.

The main objective will be to investigate whether treatment with nVNS on top of best medical practice in acute ischemic stroke patients results in smaller infarct volumes compared with the infarct volumes of patients not treated with nVNS.