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Neural and structural adaptation of human skeletal muscle to overstretch and overload through mechanical stimuli delivered by dynamometry and exoskeletons

The primary objective of this study is to establish the relationships between structural and neural adaptation of human skeletal muscle when muscles are exposed to overstretch and overload through exercise.

A Phase 3, Randomized, Double-blind, Placebo-controlled, Single-dose Study to Evaluate the Efficacy and Safety of Suvratoxumab in Mechanically Ventilated Adults and Adolescents for the Prevention of Nosocomial Pneumonia

Primary:- To evaluate the effect of suvratoxumab on reducing the incidence of nosocomial all-cause pneumonia.Secondary:- To evaluate the safety of a single IV dose of suvratoxumab.- To evaluate the effect of suvratoxumab on reducing the incidence of…

DAPARHT: DAPAgliflozin for Renal protection in Heart Transplant recipients

The DAPARHT trial is designed to assess effect of the SGLT2 inhibitor dapagliflozin to prevent deteriorating renal function in heart transplant recipients. Secondary objectives are to assess the impact of treatment on: i) weight, ii) glucose…

Military Genotyping Study: Individualizing fatigue and sleep deprivation tolerance in shift and night work

There are large interindividual differences in tolerance for night work. The main factors determining this tolerance are largely unknown, and better identifying them - which is the aim of this study - may target preventive and mitigating strategies…

Effectiveness of heat blankets in preventing hyperthermia in Dutch military personnel

The objective of the study is to determine the effectiveness of three types of heat blankets in reducing the cooling rate of the human body in arctic conditions

Prehabilitation and rehabilitation in breast cancer surgery patients: a pilot study

The objectives of the BREHAB pilot study include both process and research objectives. Analysis of the process objectives will enable the feasibility of a larger RCT to be assessed. They focus on the feasibility of prehabilitation and rehabilitation…

PRone positioN in patients with
spontanEous ventiLation and
acute hypoxemic respIratory
FailurE- The PRONELIFE
Randomized Controlled Trial

PRONELIFE is the first randomized controlled trial comparing the prone position with the supine position in patients with acute hypoxemic respiratory failure from any cause that recruits a sufficient number of patients to test the hypothesis that…

Reduction of blood loss in pediatric osteotomies around the hip
- A randomized placebo-controlled trial with tranexamic acid -

This study has been transitioned to CTIS with ID 2024-516324-34-01 check the CTIS register for the current data. To evaluate (reduction of) intraoperative blood-loss with and without pre-operative TXA administration, in children undergoing a…

A randomised controlled trial complemented with biosignal diary data to evaluate a newly developed system for work-related stress management and prevention for older adults (mHealthINX)

We hypothesise that mHealthINX will help lower stress in 50+ workers, as assessed both through pulse wave analysis & electrocardiogram analysis (i.e. biosignals captured through the hand-held SmartPWA3 developed by AIT) and self-reported…

A randomized trial of ultrasound-facilitated, catheter-directed, thrombolysis versus anticoagulation for acute intermediate-high risk pulmonary embolism: The higher-risk embolism thrombolysis study

The primary aim of the study is to evaluate whether treatment with the EKOS device on top of anticoagulation in patients with severe pulmonary embolism results in a better clinical outcome than treatment with anticoagulation alone. The primary…