312 results
To assess in a cohort of patients with established FAP:1 The efficacy of MPA in terms of reduction of number of colonic polyps, by means of Endoscopic Appearance of Polyposis (EAP) index.2 The effect on histological parameters and biological…
The primary objective is to investigate whether insulin sensitivity can be preserved postoperatively, by giving a simple carbohydrate-rich drink before surgery. Furthermore, to investigate whether gastric passage will be enhanced postoperatively…
The primary objective is to establish the neuroprotective efficacy of NAC against cisplatin-induced neurotoxicity. Mainly the sensory neuronal guidance will be assessed before and after treatment with cisplatin in a group of patients receiving NAC…
Striatal D2 receptor availability will be ascertained in 30 recent abstinent cocaine addicts by [123I]IBZM SPECT. In addition, we will measure drug craving and impulsivity with questionnaires, fMRI/EEG using cue-reactivity and impulsivity paradigms…
Investigate the effect of acidic and neutral oligosaccharides supplemented enteral nutrition on infectious morbidity, feeding tolerance and short-term outcome in VLBW infants. Furthermore, an attempt is made to elucidate the role of acidic and…
To decrease the incidence of sepsis after removal of central venous catheters in the neonatal intensive care unit.
This study will evaluate the effect of approximately 10 years of pravastatin treatment on IMT in young adults with FH. Furthermore, safety parameters and psychological aspects with respect to early treatment initiation will be investigated.
The primary goals is to determine the thermophysiological strain during the 7-hills run. Specifically, we are interested in those subjects with a core body temperature above 40 degrees. Based on additional research, we aim to gain better insight…
Psyfit: a randomised controlled trial to study the effectiveness of an online mental fitness program
The aim of the study is to evaluate the effectiveness of Psyfit, an online mental fitness program.
The objective of the present study is to assess the clinical and cost-effectiveness of the combination of Mindfulness Based Cognitive Therapy (MBCT) and Optimal Medical Management (OMM) in terms of reducing the risk of relapse and recurrence in…
The aim of this study is to evaluate whether a 30-minute episode of helium breathing in humans affects the ability of the immune system to respond to ex vivo stimulation in whole blood taken from healthy volunteers.
To quantify the impact of outpatient nurse-led prevention clinics on the risk of future clinical events in patients with symptomatic coronary artery disease.
To investigate whether Misoprostol (compared to placebo) will diminish the amount of insertion failures. To investigate whether Misoprostol (compared to placebo) will diminish the amount of insertion related complications (eg. syncope, perforation…
1. Primary end point is achievement of a negative cross-match test with the donor kidney and transplantability.2. Secondary objectives are patient and graft survival, graft function as assessed by calculated creatinine clearance, proteinuria, the…
In The Netherlands 2% of women and 4% of men suffer from Obstructive Sleep Apnea Syndrome (OSAS). NCPAP, the gold standard therapy for moderate to severe OSAS has been shown to reduce blood pressure in OSAS. NCPAP therapy is however hampered by…
-To test the efficacy and determine the costs of a multifaceted intervention program to reduce falls incidence rate and fear of falling, and thereby improve mental wellbeing in community dwelling frail elders, with high level of comorbidity and…
The purpose of this pilot study is to evaluate the fall training in older individuals by reduction of hip impact forces. Furthermore, to determine if older individuals are able to perform these fall techniques after training, fall performance is…
Study the risk of colorectal adenomas in patients detected with duodenal adenomas.
The main objective of the study is to evaluate the effectiveness of an individually- based lifestyle intervention for male workers with an elevated CVD risk in the construction industry in The Netherlands.