436 results
Primary objectives:1) To determine whether concurrent ATII-antagonist treatment can prevent trastuzumab-related cardiotoxicity, defined as a decline in LVEF of more than 15% or a decrease to an absolute value <45%Secondary objectives:1) To…
In the light of the aforementioned the current study has three objectives: 1) to study the effectiveness of an in-home self-management intervention to reduce fear of falling, avoidance behavior, catastrophizing about falls in order to prevent…
To monitor the thermoregulatory reponse and the disturbances of the fluid- and electrolyte balance during a marathon. Moreover the incidence of hyperthermia and dehydration is determined, whilst the fluid balance of participants with and without…
Goals:1.To estimate the effect size for our primary and secondary outcome measures, allowing us to perform a more reliable power estimate for the actual trial.The primary objective of this pilot study is to determine whether a non-pharmacological…
Primary Objective: • To determine the incidence rate of self-reported ILI.Secondary Objectives: • To determine the efficacy of 13vPnC in preventing a first episode of self-reported LRTI.• To explore the effect of 13vPnC on the incidence of self-…
2.1 Primary Objective: To evaluate the feasibility of RenalGuard for diuresis-guided fluid replacement therapy (ability to match in and output) (time to desired diuresis>200ml/hour) To evaluate the safety of forced diuresis and fluid…
The primary goal of this study is to assess how M4M affects acceptance of antipsychotic depot medication, during the intervention and after terminating the intervention.
In this present study we will assess the effect of a pre-warming intervention before surgery, in order to decrease the temperature gradient from core to periphery and thereby minimize redistribution hypothermia under anesthesia, on (I) the…
The (cost) effectiveness of an intervention on energy balance related behaviours and work engagement
The study aims to develop an intervention to improve workers' energy balance related lifestyle behaviours (EBRB) to prevent overweight and to improve work engagement and subsequently evaluate the intervention developed.
The goal of this study is to develop and test two tailored intervention programs to stimulate pregnant women to stop drinking alcohol. These intervention programs are a health counseling and a computer tailored intervention. The efficacy of the…
Controlling the glycemic impact of food products may reduce glycemic and insulinemic responses. This may result in a decreased inhibition of fat oxidation rate and lower plasma TAG concentration. A higher postprandial fat oxidation may result in…
The main objective is to translate and adapt the Adolescent Cannabis Check-Up (ACCU) to the Dutch context and setting, and to evaluate its effects on the cannabis use of adolescents in the Netherlands. The Dutch version of the ACCU is called Wiet-…
We would like to conduct a RCT to confirm the hernia prevention effect of a mesh, however in a slightly different position, with a different mesh and with all types of stomas. In addition, we want to measure the possible benefit in terms of quality…
To investigate the incidence of CIN in three hospitals where patients are treatedaccording to the current guidelines, to identify the prediction risk factors and toobtain blood and urine samples that will allow future identification and evaluation…
To compare dose homogeneity and heart and lung doses in supine and prone position. Furthermore, the reproducibility of prone position will be compared to standard supine position, and we aim to identify those patients who benefit most from prone…
The effect of the dipeptide alanyl-glutamine, intravenously or enterally and perioperatively given, on postoperative insulin resistance in colon cancer patients.
The objective of the study is to investigate if respiratory feedback training as an additional rehabilitation method after acute myocardial infarction might improve quality of live Primary objective: Is quality of live as measured by the "Heart…
The primary objective of this study is to evaluate if there are differences in the tissue-interface pressures, pressures inside the tissues and tissue deformation in the sacral area when volunteers lie on a regular spineboard versus a vacuum…
a. To study whether a specific set of biomarkers is associated with PE with DVb. To study whether a specific set of biomarkers is predictive of PE with DV.
The primary purpose of this study is to determine the relation between a physically active lifestyle and the primary and secondary prevention of diseases and death.Using an online questionnaire, we will approach all civilian participants of the…