365 results
We hypothesize that CTC detection through diagnostic leukapheresis improves the detection rate among ER+, N+ primary breast cancer who have received 5 years of adjuvant endocrine therapy and will be a promising technique for risk classification in…
To establish the diagnostisch accuracy of ultrasound for the exclusion of fracture of the elbow
To determine whether micellar curcumin is able to restore functional lymphocytes in pancreatic cancer patients with stable disease after standard of care treatment.
The primary objective of this study is to determine the feasibility of intraoperative fluorescence imaging detection of PitNET tissue during TSS using the VEGF-targeting optical agent bevacizumab-800CW in tumors with a Knosp grade of 3 or 4.…
The purpose of this study is to investigate how well a new dosage form of tildrakizumab is tolerated when it is administered to healthy volunteers. Tildrakizumab (also known as Ilumetri) is no new compound; it is already available on the market as a…
The primary objective of this study is to investigate the quality and content of the MTT-EP model in response to electrocutaneous stimuli by determining stimulus-related and/or physiological-related components, before and after the occurrence of HFS…
In this non-inferiority study, we aim to identify the diagnostic value of indocyanine green (ICG) fluorescence imaging for SLN mapping versus the standard-of-care 99mTc in the SLN procedure for breast cancer patients.
The current study aims to assess the impact of self-quarantine on glycemic control. In addition, this study describes diabetes self-management, well-being and distress in Dutch patients with type 1 and type 2 diabetes, during a nationwide period of…
The goal of this study is to gain insight into the eating behaviors of women with an eating disorder (ED) and comorbid autism spectrum disorder (ASD). By comparing this group to two other groups (women with an ED but without ASD and women with an…
The primary goal of this research project is to study physiological responses of typically developing (TD) children and children with CP (only if the results of TD children are promising) to discomfort induced by the use of technological devices…
To establish a point prevalence of asymptomatic proximal lower extremity DVT in patients admitted to the ward with COVID-19.
Primary Objective: This study aims to analyze cycling gross efficiency, pedalling power symmetry, and hip, knee, ankle kinematics in adults with a transtibial amputation in different foot positions and seat heightsSecondary Objective(s): The second…
The primary objective of this study is to demonstrate that our DLA-based method is promising enough to detect CTCs in ER+, N+ primary breast cancer patients after 5 years ET. Simultaneously, other methods (CTC detection in 7.5 ml and 30 ml of blood…
The current study investigates which brain areas are related to habituation of pain (using fMRI) and enables a direct coupling with concurrent EEG. We will test the hypothesis that activation of areas in the brain show changes over time as correlate…
The WIDE project aims to investigate if implementation of WGS in molecular diagnostics is feasible in routine practice at the Netherlands Cancer Institute (NKI).
The aim of this present feasibility study is to determine the safety and preliminary accuracy by which we can intra-operatively detect residual disease in esophageal tumor and lymph nodes. This study is set up as a prospective multi-centre dose…
Detecting and quantifying the cardiac cycle-related pulsatility of the intracranial aneurysm wall with 4D CTA. Besides, the pulsating belbs will be differentiated from noise-induced pulsations.
The primary objective of this study is to confirm that the dissolution profiles of a sugar-free and sugared lozenge containing CPC/benzocaine (1.4mg/10 mg) are comparable following a single dose in healthy adult subjects.The secondary objectives of…
Understanding the specific vs. generalized role of the prefrontal cortex for prosocial decision-making. In particular, we want to investigate whether the prefrontal cortex is recruited during the evaluation of the abstract cost-benefit ratio of one*…
The primary objective is to investigate the current prevalence of IAH and severe hypoglycaemia (SH) in individuals with diabetes type 1.The secondary objectives are:- Study the change of IAH over time in individuals with diabetes type 1.- Study risk…