41 results
With this research project we will investigate the relationship between SSRI concentration in the (pre)term neonate and clinical short and long term effects on the neonate after exposure to SSRI*s during pregnancy and lactation. Furthermore, the…
The purpose of this research project is to improve the overall quality and resolution of the MRI images, to correct for movement effects during the procedure and to speed up the investigation. The goal is to enhance and standardize a technique…
To identify alternative dEMG electrode positions in preterm infants for cardio-respiratory monitoring.
The aim of our project is to perform a novel mass screening to detect CD in 12 months-4 years old children who visit the YHCCs in a well-described region in the Netherlands, to show that it is feasible, efficient, cost-effective and well accepted by…
The aim of this study is to determine novel (bio)markers that show a stronger correlation with signs of over- and under-treatment than the conventional adrenal steroid profile in children with CAH.
To validate two less complex techniques, electrical activity of the diaphragm and ultrasound of the diaphragm, compared to the gold standard (transdiaphragmatic pressures) for monitoring diaphragm function and inspiratory effort during assisted MV…
main objective: Investigate the prevalence of liver fibrosis according to TE values in children enrolled in a HPN-program. Secondary objectives: Investigate the correlation between TE values and ELF test score and APRI in children enrolled in a HPN-…
To obtain reference values of rsO2 of cerebral and muscle tissue measured by NIRO 200 NX for (relatively) healthy near term and term neonates.
The main objective of our study is to disentangle the factors that determine the quality of life in children and adolescents with intellectual developmental disorders and psychiatric disorders, and in the process, develop a more systematic and…
To study the effects of varying amounts of air and patient position on oesophageal pressure measurements in children with and without lung injury.
Primary question:Are dEMG measurements a clinical marker to assess the WOB in preterm born neonates?
To investigate whether atopic dermatitis patients can be stratified based on integral analysis of clinical patient data complemented by novel biophysical measurements, in-vivo Raman spectroscopy, microbiome swabs and a oral mucosa swab (one time).
PRIMARY* To demonstrate the non-inferiority of intravenous-to-oral antibiotic switch therapy in clinically stable neonates with probable bacterial infection compared to a complete course of intravenous antibiotic therapySECONDARY* To describe the…
Purpose of the clinical study: To evaluate the effectiveness, safety and usability of real time continuous glucose monitoring (rCGM) in neonatal intensive care (NICU)Primary objective:* To evaluate the effectiveness of rCGM in the regulation of…
The objective is to find the most effective combination of wearable devices to accurately reflect paediatric asthma control in a home monitoring situation, by studying the relation of the home-measured signals to the currently used exercise…
To investigate the association between preterm brain injury, impaired brain development and neurodevelopmental outcomes 9-10 years after VPT birth
The primary objective of this pilot study is to compare the venous infliximab blood level and anti-drug-antibodies with the bloodspot-technology in children with inflammatory bowel disease. The hypothesis is that there will be a good correlation…
The current pilot-study aims to validate Virtual Reality (VR) environments that elicit variance in virtual aggression and social information processing (SIP) and consist of the following research questions.1. Do children experience VR environments…
Main aim:Identify the optimal urinary catecholamine metabolites panel for neuroblastoma diagnostics.Sub-aims:1. Investigate whether catecholamine metabolites can also be linked to prognosis and thus assist in risk assessment.2. Investigate whether…
The main objective of the study is to quantify functional gait abilities in children with DCD. The second goal is to evaluate whether their gait abilities can be improved by training.