25 results
Point of care testing with Fcal POCT will reduce substantial the referral rate of children with chronic GI symptoms to the paediatrician.
The standard-of-care sentinel lymph node (SLN) procedure in paediatric cancer patients consists of a preoperative intradermal injection with 99mTechnetium-nanocolloid as radiotracer in combination with an intraoperative injection of blue dye for…
Primary Objective:The main objective of this study is to investigate the effectiveness of BEAR (a parent training combining e-learning and home visits) compared to care-as-usual (CAU) in young children (12-30 months) who are at risk of developing…
With this study, we aim to shed light on the possible use of diagnostic next generation sequencing in DLD, by determining the diagnostic yield of WGS in this important class of neurodevelopmental disorder. In addition to determining this diagnostic…
To demonstrate that novel MEG sensors can be used successfully in clinical practice, and to demonstrate their effectiveness as a powerful diagnostic tool in epilepsy.
Investigation of the blood B cell compartment in family members of CVID patients (with and without a CVID family history) to identify or exclude B-cell defects and to improve our insight into a potential familial background of CVID.
To study the neural basis of i) general movements including the transition to the last phase of general movements, the fidgety movements, en ii) the transition from general movements into goal-directed movements using electromyography (EMG),…
The primary objectives of this study are:1. to investigate the association between both conventional and alternative coagulation tests, and hemostatic complications, including bleeding and clotting complications in pediatric ECMO patients2. to…
Primary objective: To determine the prevalence of AKI in critically ill children based on clearance of iohexol.Secondary objectives:1. To determine the prevalence of AKI in critically ill children using serum creatinine, creatinine clearance,…
The primary objective is the development of a computer-aided diagnosis tool (CAD-tool) that enables specialists to improve the diagnosis, treatment, and evaluation of hyperkinetic movement disorders. The secondary objectives is are: 1) To analyze…
Our research project aims to answer 3 key questions:1. How do MBW, spirometry and body-plethysmography outcomes compare in survivors of CDH?2. What is the relation between MBW outcomes in survivors of CDH and age?3. Are prognostic factors of the…
The main goal of this study is to test the feasibility of two different operant conditioning methods to decrease hyperreflexia of children with CP/SP/HSP, using real-time visual feedback.
Primary objective:To study whether changes in OCT parameters lead to earlier detection of visual decline compared to standard ophthalmological testing (visual field, visual acuity) in children with a brain tumor. Secondary objective: To study the…
To determine the accuracy of US for detecting disease activity in paediatric patients with IBD and to develop an easy-to-use and accurate US-activity index that can accelerate and improve clinical management by reducing the need for gastrointestinal…
The objective of this study is to test whether the assays described above are feasible to predict bronchopulmonary dysplasia in premature infants.
Primary objective:- Determine whether PCT, measured in cord blood, and the blood of the neonate, is suitable to determine the presence or absence of neonatal infection.Secondary objective:- To investigate whether PCT is a suitable parameter to…
The primary objective of the study is to develop new sensitive and quantitative outcome measures for clinical trials in ALD. The secondary objective is to identify biomarkers to stratify patients based on disease progression rate.
Primarily, to assess the effect of changing CO2 levels on the sublingual microcirculation, cerebral oxygenation, and cerebral perfusion. Secondarily, to assess if and how sublingual microcirculatory parameters, parameters of cerebral oxygenation,…
PQ-110-004, is designed to evaluate if a mobility course using multiple light levels simulating real world conditions, can detect changes in vision in subjects with a phenotype representative of LCA Type 10 and therefore serves as an assessment tool…
Primary objective; To asses the accuracy and precision, the criterion validity of the app compared to the goniometer and the inter and intra observer reliability Secondary objective; To evaluate the applicability of the PROSUP mobile phone…