18 results
The aim of this study is to establish the accuracy of Molecular Culture for prediciting the outcome of the traditional blood culture.
Primary objective: To quantify the degree of respiratory muscle degeneration and dysfunction using ultrasound in patients with DMD over a wide age range; from early childhood to adults.Secondary objective: To determine the association between…
Over the last decades, much fundamental knowledge has been obtained about the neurobiology of antisocial behavior on group level. The main aim of the current study is to translate this group-level knowledge to individualized, developmental profiles…
A future project will focus on a new platform for at-home monitoring and testing of cochlear implants, developed by one of the manufacturers of cochlear implants, Advanced Bionics (AB). Their Research Application allows for clinicians to read out…
Specific Aim 1) To identify the frequency and risk factors for PVA and its subtypes in ventilated children, with a specific focus on DC breaths. Hypothesis: PVA subtypes related to inadequate ventilator support (flow undershoot and premature cycling…
Primary objective of this clinical investigation is to evaluate superiority of the signal quality of SOFT ECoG flexible high-density electrode grids compared to regular high-density electrode grids, routinely used at the UMC Utrecht. The signal…
Primary Objective:1) To determine the efficacy of personalized progressive resistance training (PRT) on muscle strength of elbow flexors in children and adolescents with Spinal Muscular Atrophy and Congenital Myopathy compared to usual care…
Identification of possible genetic modifiers, that will advance the knowledge on the pathomechanisms of aortopathy.Hopefully this will offer promising new leads to novel therapeutic that will allow to individualize current treatment protocols to…
As verbs are better indicators of everyday language ability than nouns, the current project characterizes verb processing and verb learning abilities of children with PPFTs, and compares them to the abilities of typically developing children (aim 1…
The primary objective:To identify fluid and radiological biomarkers, in IA carriers, AHD patients, and EoHD patients, that can be linked to clinical outcome measures. We aim to link longitudinal changes in these biomarkers to disease progression.…
IRDs are genetically diverse (280 causative genes have been identified to date) (https://sph.uth.edu/retnet/) and have vastly different clinical manifestations, including age of onset, severity of disease, rate of progression, and structural and…
In the current study, we aim to assess the energy requirements of professional football players during different phases in the rehabilitation from an ACL reconstruction. As such, this study will identify the energy and nutritional requirements,…
The key objective of this study is to determine the clinical significance of using MRI scans as a diagnostic tool to assess velopharyngeal insufficiency in cleft palate patients.
Primary Aim: to validate 3D Spiro MRI against PCD-CT for accurate phenotyping and sensitive monitoring of children with CPPD, by assessing disease severity in term of regional lung structural and functional changes compared to PCD-CT.Secondary aim(s…
The primary aim of this clinical trial and healthcare evaluation (in Dutch: Zorgevaluatie) is to compare the diagnostic value of two diagnostic EEG strategies (repeated EEG with and without prior sleep deprivation) frequently applied in current…
The prognostic accuracy of combining these four criteria to predict the later development of personality disorders (with/without psychosocial breakdown) is investigated in a longitudinal study. From this, a selection of items with the strongest…
To investigate copeptin levels in pediatric polyuric tubulopathies such as Nephrogenic Diabetes Insipidus (NDI), Renal Fanconi syndrome and Bartter syndrome to use it as biomarker for the volume state of these patients.
1. Primary objective:The primary aim of this study is to investigate the predictive value of OCT parameters at diagnosis for long-term (4-5 years after diagnosis) visual impairment (visual acuity, visual field) in children with a primary brain tumor…