759 results
Primary Objective: • To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors. In other words, the aim is to investigate whether a more optimal…
Identification of genetic risk factors for development of type 2 diabetes, diabetes related diseases and complications. Furthermore the examination of the relationship between genetic variation, biochemical factors, environmental factors (obesity…
The proposed project focuses on: a) implementation of an improved, standardized method for performing quantitative nailfold capillaroscopy to visualize morphological patterns and evaluate its diagnostic use in patients with (possible) CTD and…
Study 1:The ultimate goal is to abrogate or reduce the excessive burden of carcinomas in organ transplant patients. We aim to elucidate and establish consistent changes in genomic and expression (both mRNA and miRNA) profiles in the course of tumor…
2.1 Primary objectives Primary objective is scientific research to study the additional effect of bevacizumab on hypoxia related parameters. 2.2 Secondary objectives a) To compare the efficacy of bevacizumab with pre-treatment obtained values of…
Is SV2A expression in surgically removed tumour and tumour-surrounding tissue of glioma patients suffering from epilepsy correlated with their clinical response to levetiracetam?
This study is focused on determination of risk factors associated with preeclampsia and intrauterine growth restriction, both develop in early pregnancy. These pregnancy complications are associated with cardiovascular diseases in later life. We…
1 Primary Objective To investigate the effects of 15* liver ischemia versus 30* liver ischemia on liver injury and liver function.To investigate the effect of liver manipulation during mobilisation for a right hemihepatectomy, that can be used as a…
This study aims to identify qualitative and quantitative differences in innate, cellular and humoral immune response between persistent, intermittent and noncarriers of S. aureus.
Primary objective:To determine the most important risk factors for falls in elderly people with mental retardation and to describe which of these factors may be modified by intervention/treatment, in order to prevent falls.Secondary objective:To…
The present study will focus on the consequences of long-term delay of puberty induced by treatment with Decapeptyl-CR. We will investigate the effects of this treatment in regard to brain functioning, brain development, various endocrine, metabolic…
The main aim of this study is to assess the prevalence of allergic and non-allergic health problems in veterinary students in different phases of the veterinary education. On later stage, genetic predisposition for allergies will be studied. In the…
the study aims to answer the following question:are components of innate immunity in general, and the complementsystem in particular, correlated with and usefull as predictors for the occurrence of macro- and/or microvascular complications in a high…
The study objectives are:1. Getting insight into the biological origin of the typical serum protein profile in breast cancer by comparing the protein profiles in breast tissue of benign breast disease patients and primary breast cancer patients with…
The general objective of this study is to elucidate the cellular components for HIV-1 infection in children.
In this trial we will investigate the following hypothesis:- Uremic vasculopathy develops, not only in large and medium sized conduit vessels, but also in the microcirculation.- There is a relationship between the rate of microcirculatory…
Detection of High Intensity Transient Signals as hemodynamic parameter in patients undergoing aortic valve replacement
The goal of this study is examining the acute effects of insulin on microcirculation in hypertensive insulinresistant subjects and investigate if angiotensine II influences these effects. Amendement: The goal of the amendement is to exame the…
To examine the effect of surgical trauma on mucosal perfusion, intestinal epithelial damage, the inflammatory response and potentially sepsis, following surgery remote to the abdomen in adults, children and neonates,
In the present study we aim to identify the genetic modifiers in this family which underlie differences in severity and type of phenotype by means of linkage analysis.