3889 results
Primary Objective: • To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors. In other words, the aim is to investigate whether a more optimal…
The primary goal is to investigate whether there are deficits in the response inhibition and performance monitoring in cannabis dependent patients on both a behavioral and an electrophyisiological level. The secondary goals are to investigate…
The objective of this study is to investigate:1) the prevalence of insomnia in patients with T2D with and without depression2) whether insomnia in patients with T2D with and without depression, is associated with increased levens of HbA1C3) whether…
The main objective of this study is to characterize the flow of information in the fronto-parietal network during the simulation of movements using intracranial EEG recordings. In the characterization we will pinpoint the neuronal (sub)regions of…
Objective: To assess the effect of beer consumption, with a range of alcohol content, on fluid balance after exercise-induced dehydration. Hypothesis: Based on the glucose and electrolyte composition of beer, and the blurred effect of alcohol in the…
In the present study the prevalence of and risk factors for vitamin D deficiency will be determined in a patient population with a fracture in the upper or lower extremity.
The aim of this study is the histopathological analysis of venous injury using mechanochemical endovenous ablation
The major research objective is to examine if acute exercise results in a more pronounced increase in acetylcarnitine concentration in sedentary subjects compared to endurance-trained subjects and if the exercise-induced increase in acetylcarnitine…
to investigate functional characteristics of immune cells from MS patients, including migratory capacity, inflammasome activity and Breg cell function and compare these to healthy control subjects 2) to assess possible differences with regard to the…
To further investigate the application in a clinical setting we aim to set up a model in which we can investigate the protective effects in an in vitro model, where subjects blood serum is used to transfer the protective effect of RIPC onto cells…
(1) To asses the influence of P-gp function at the BBB on flumazenil binding to the GABAA-receptor in pharmacoresistant patients with temporal lobe epilepsy (TLE), using PET and [11C]flumazenil as a ligand and tariquidar as P-gp blocker. (2) If we…
The aim of this pilot study is to assess whether the cerebral metabolic changes in RA patients, are also present in CD patients with active disease and fatigue. The influence of chronic inflammation on cerebral metabolism in CD patients will be…
The aim of the present study is to identify aberrations that play a significant role in therapy response of ovarian cancer patients. RNA sequence/expression and protein expression data will be combined and correlated to the extensive clinical follow…
To investigate the effect of different sitting positions that are experienced in public transport by people of taller or shorter height than average on venous blood flow.
The main aim of the present study is to improve our understanding of the role of blood-brain barrier function and cerebral perfusion in dementia of the Alzheimer*s type.
In the current study we will re-examine the participants of the CODAM study in a second follow-up evaluation (12 yrs after baseline) in order to obtain further longitudinal information on the natural development of type 2 diabetes and cardiovascular…
The objective of the study comprises the identification of (tissue) biomarkers related to the risk of re-amputaion, systemic atehrosclerotic manifestations and woundhealing in patients with critical limb ischemia by investigating tissue biopts at…
The aim of the present research proposal is to metabolically phenotype endurance trained athletes, lean and obese sedentary and type 2 diabetic individuals with the following objectives:(1) To assess metabolic flexibility as measured by a euglycemic…
1. To assess neuroimaging hallmarks of RVCL disease stages;2. To evaluate cerebrovascular reactivity as a biomarker of endothelial (dys)function in RVCL patients, in migraine patients and healthy controls;3. To identify shared pathophysiological…
The objective of the study is to answer the following research questions:1) What differences do exist in functional connectivity between patients with unipolar depression and healthy controls? 2) Can changes in functional connectivity be used as…