205 results
Primary Objective: To investigate whether differences exist in muscle function, muscle energy metabolism and cardiorespiratory fitness in CML patients with muscle complaints, compared to CML patients without muscle complaints, and controls (non-CML…
To determine the effect of RIPC on MINS in patients after pancreatic sugery.
Our objective is to use magnetic resonance imaging (MRI) to investigate the neural changes after repeated transcranial direct current stimulation during an episodic memory task in patients with mild cognitive impairment and in healthy age-matched…
To study the efficiency of visual information processing in patients with retinal disorders.
The following research questions will be addressed in two different studies:1. Do addicted patients with high scores on psychopathy have reduced empathic concern associated with reduced LPP amplitude and mu-suppression during an empathy task? 2. Are…
Investigating the molecular and phenotypic differences of iPSCs established from skin fibroblasts of discordant MZ BWS twin pairs.
To assess the effects of marathon running on changes in cardiac and skeletal muscle structure and function using state of the art MRI techniques, ultra-sensitive biomarker assays and a high resolution 64-lead electrocardiogram.
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with CADASIL, relative to controls.
The objectives are to study short-term changes in lung function, exhaled NO, respiratory symptoms and bronchodilator medication use in association with short-term changes in UFP in general and UFP from aircraft emissions specifically in children…
The purpose of this study is to find out which common problems occur in the HME patient population. Furthermore the study will investigate which factors are associated with the observed problems. This is barely investigated in the current literature…
To investigate the impact of (a disrupted) circadian rhythm on food preferences and chemosensory perception.
The primary objective is to study glaucomatous structural brain changes in a longitudinal manner, and how it relates to visual functional loss and glaucomatous retinal changes over time.
1. To investigate the influence of different immunosuppressive drugs on the immune response of placental derived mononuclear cells, peripheral blood derived mononuclear cells, and cord blood derived mononuclear cells.2. To investigate the neonatal…
To identify brain determinants (moderators) and mechanisms (mediators) of ADHD persistence into adulthood by studying fine-grained neuroanatomy and connectivity in a longitudinal study of genetically stratified patients across the full spectrum of…
to determine if there is an alternative mechanism for urine acidification in men in response to NH4Cl other than that through ENaC
To study the pharmacokinetics of non-reactive labelled histidine (L-HISTIDINE:HCL:H2O (D5, 98%; 15N3,98%) and the effect on intestinal imidazole propionate (IP)production in small intestine vs colon in healthy controls, metabolic syndrome and DM2…
The main objective of this study is to investigate whether a long lasting pro-inflammatory phenotype, the characteristic of trained immunity, is present in circulating monocytes of patients with severe periodontal disease and whether this correlates…
In this study we use a unique paradigm which can be used to examine both high-level (serial dependence) effects as low-level (adaptation) effects. By doing so we hope to resolve the discrepancy in the previous findings. We expect that low-level…
Area of interest (study setting): Specific aims:Transient triggers and chronic riskfactors (case-crossover and casecontrol)(1) To investigate frequency and strength of association between transient physical andpsychological triggers and early-onset…
To investigate whether long-term activation of the innate immune system, named *trained innate immunity*, occurs at the level of the bone marrow progenitor cells in patients with significant coronary artery disease and whether this correlates with…