139 results
To assess the association between secondary brain injury in intracranial haemorrhage and the involved inflammatory response. We want to correlate perihematomal inflammation, serum inflammation markers, increased blood-brain-barrier leakage and…
To assess the potential of AT1R and ETAR antibodies to serve as a biomarkers for clinical deterioration in COVID-19.
The primary objective is to develop algorithms that define digital biomarkers for disease progression in Progressive Supranuclear Palsy patients. The biomarkers, when developed systematically, can eventually serve as primary or secondary clinical…
The primary objective is to study the association between baseline (including genetic), and repeatedly measured blood biomarkers (including metabolomics and proteomics), and the incidence of cardiovascular disease. Secondary objectives are related…
The primary objective of this study is to identify the distinct roles of the peripheral and central nervous system in the subjective experience of panic.
The primary objective is to measure the dose of cerebral ischemia, as a measure of cerebral hypoperfusion, before, during and after aortic arch surgery. Secondary objectives include parameters that influence the occurrence of cerebral ischemia (…
6.2.1 Primary objective The primary objective is to assess the effectiveness of a stepwise medical therapy approach guided by coronary function testing in reducing angina burden of patients with angina pectoris and no obstructive epicardial coronary…
The primary objective of this study is to characterize the immune cell composition and epithelial-immune cell crosstalks in patients with CF. The endpoint will be constituted from several read-outs on peripheral blood mononuclear cells (PBMC's…
Main objective: 1. To determine the feasibility of measuring fat replacement, atrophy and inflammation using MRI in several muscle groups in Myasthenia gravis patients, by determining scan quality and the difference in these parameters between MG…
We expect the BMI and the type of fat distribution to have a significant influence on the change in hormone levels, fat metabolism and systemic inflammation levels after bilateral salpingo-oophorectomy (BSO). In patients with endometrial cancer,…
This study aims to investigate the contribution of remote propagation waves in the tactile perception of two important material properties, namely roughness and hardness.While it is known that propagation waves arise and information is available…
Primary• To describe the incidence, aetiology and viral loads of (a)symptomatic viral respiratory infections in adults (18-40 years) who live in shared housing with at least 3 other adults during the peak common cold season in the…
We aim to study individual changes in phenotypic characteristics of cardio-metabolic health, and of cognitive and physical performance over a time span of 11 to 19 years in older individuals previously included in the Leiden Longevity Study. This…
The general aim of this study is to gain knowledge on the impact of ConAoS in adult patients, studying the aortic valve itself, the left ventricle and the aorta. The following primary objective is conducted: to describe the prevalence and pattern of…
Brain tumors: Characterize and quantify changes in immune parameters during disease in patients with a CNS malignancyAML: Characterize and quantify changes in immune parameters and immunotherapeutic targets during disease in pediatric patients with…
To validate biomarkers that are associated with severe RSV infection and respiratory sequelae.
We hypothesize that one possible mechanism may involve the free radical formation. Therefore, measuring free radical generation will be correlated to the diversity of seminal microbiota and related with semen-parameters defined by the WHO guidelines…
To optimize (early) diagnosis and risk-stratification of (early) cardiomyopathy phenotypes and to create a better understanding of underlying pathophysiological processes.
The objectives of the current study, are to assess in a sample of remitted recurrently depressed patients over a 20-year follow up period: the long-term effects of PCT; the long-term predictive value of cognitive functioning on relapse and daily…
To determine the occurrence and natural history of (subclinical) cardiac abnormalities during hospital admission for COVID-19 and the possible cardiovascular complications short-tem (6 months) and long-term (1,2,5,10 years) post-admission.