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Hunger Winter Generations Study (The HWG Study)

The objective of this study is to investigate whether the differences in DNA methylation between individuals who were exposed in utero to the Dutch Hungerwinter (F1) and their non-exposed, same-sex siblings (F1) - as identified in epigenome-wide…

Functional magnetic resonance imaging of human hypothalamic responses to oral glucose ingestion in obese and lean subjects

The objective of the study is to determine hypothalamic function in response to oral glucose ingestion in obese subjects.

Effects of IVF culture conditions on the embryonic genome, methylome and transcriptome: a study to evaluate the safety and quality of different culture systems

To study the effects of in vitro culture conditions, such as different culture media or oxygen tension, on omic layers (i.e. genome, epigenome and transcriptome) of preimplantation human embryos and to relate this to chromosoom instability (CIN).

The Effect of Renin-Angiotensin System Inhibition on Aortic Dilatation Rate in Patients with Coarctation of the Aorta.

Our main objective is to evaluate the effect of RAS inhibition on ascending aortic dilatation rate by cardiac magnetic resonance (CMR) imaging in CoA patients, and compare this to CoA patients without RAS inhibition. As secondary objectives, we aim…

A non-invasive exercise test for evaluating sport-related arterial blood flow limitation in the leg: an exploratory study

Our main aim for the future is to improve diagnostic testing for FLIA. NIRS and pedal force measurements are very promising in this respect, since they may be used in a clinical setting, in a research laboratory, and in the field in a high-…