6380 results
Our project aims to investigate cognitive and linguistic deficits in people with SCD, focusing on working memory impairments, deficits of lexical access, and deficits brought on by syntactic complexity. We will integrate clinical linguistic findings…
The primary objective of phase 1 is to validate a new ELISA measurement that can determine hIAPP oligomers reliably in plasma, and of phase 2 is to correlate pathogenic oligomer hIAPP (in plasma and skin) with pain and sensory disturbances in CIAP…
Primary Objective: to assess brain kinetics of glutamate, GABA and dopamine and the associated functional connectivity of the mesocorticolimbic circuit during the absorption and elimination phase of JWH-018, as compared to the control condition.…
The primary aim of this study is to determine the causal relationship between the accumulation and inflammation of perivascular adipose tissue (PVAT) and insulin-stimulated glucose uptake in skeletal muscle, measured using dynamic PET-CTA, in…
We aim to collect blood cells from 40 patients with monogenic epilepsy, with a preference for patients with a pathogenic variant in SCN1A, reprogram these cells into iPSCs and use these iPSCs for differentiation into neurons and neuronal organoids…
The aim of this study is to investigate whether the transfer of antibodies from mother to infant is less effective in infants with intrauterine growth restriction (FGR) compared to term-born infants without intrauterine growth restriction or who are…
To assess the feasibility of the Virtual Ward in six pre-defined sub-cohorts of non-elective hospitalized patients within the current Dutch healthcar
The primary objective of this study is to be able to better assess progression of visual pathway damage in advanced glaucoma cases in particular. For this, we will use a unique combination of OCTA and dMRI techniques. In particular, we aim to relate…
To study anti-SARS-CoV-2 antibody-mediated inflammatory responses by macrophages in individuals with obesity.
Primary objective: To investigate the effects of fully inhibiting type 2 inflammation on esophageal mucosal barrier function and inflammation in adult EoE patients. Secondary objective: To evaluate the effect of type 2 inflammation and the IL4 /…
Primary objective: To establish a controlled human infection model for C. difficile which is safe, well tolerated and results in microbiological and clinical endpoint in ideally >=70% of volunteers. Secondary objectives:- Assess colonisation…
Primary Objective: To explore the computations which occur in the brain which occur in visual disorders and determine how these differ from healthy controls. Specifically, we expect that the overall sensitivity (area under the curve) which reflects…
The current trial aims to assess and validate atrial fibrillation detection and monitoring by the Corsano CardioWatch 287-2 in a remote setting across multiple international centres. By: a) To compare episodes of atrial fibrillation across 30-second…
Primary objective: To longitudinally characterize alterations in electrophysiological biomarkers in ALS of peripheral excitability in relation to neurodegeneration. Secundary objectives:1. To determine the value of multi-muscle CMAP-scan outcomes as…
The main aim of the study is to compare the optimal protein intake of a protein with a high quality (milk) to the optimal protein intake of a protein with a low quality (wheat) in healthy older adults using the indicator amino acid oxidation (IAAO)…
This study aims to be the first to visualise changes in both clitoris and pelvic floor musculature following testosterone administration and to explore how these changes relate to sexual function. The primary objective of this observational study is…
Primary Objective: The central focus of the 7T study is to investigate the influence of sleep and its various stages, particularly slow wave sleep, on CSF mobility within perivascular spaces.The primary aim of the 3T experiment is to explore the…
The aim of this study is to evaluate the added benefit of integrating genetic information and state-of-the-art phenotypic information (clinical measurements) of the musculoskeletal system in groups of patients with conditions presenting with or at…
We aim to identify if pediatric PAH patients have increased plasma IL-1β and IL-18 compared to control participants, as well as increased caspase-1 cleavage and NLRP3, IL-1β and IL-18 mRNA expression in PBMCs, reflective of inflammasome activation.…
Identify the functional and structural connectomes related to tremor control and to DBS-induced ataxia in patients with ET. The aim of the FINEST study is to improve the treatment of patients with ET and DBS-induced ataxia, by using the connectome…