33 results
The AMSTAD-OCD study aims to contribute to the improvement of outcome in OCD by identifying the determinants of a chronic course.
The primary objective is to identify clinical and biological measures that discriminate paediatric ME/CFS and post-COVID patients from healthy controls based on either clinical (based on physiological tests and questionnaires) and biological (based…
Primary Objectives are to• identify novel (likely) pathogenic genetic variants in familial or young AF patients.• investigate the relation between genetic profiles and electrical (AF) phenotypes.• develop a specific gene panel for AF• construct a…
This study has been transitioned to CTIS with ID 2024-520305-39-00 check the CTIS register for the current data. Primary objective: to evaluate the efficacy of LSD 25µg every 3 days for 3 weeks in cCH. Additional objectives:- To evaluate the safety…
Primary Objective: To investigate motor developmental outcome at school age of children with CHD compared to typically developing peers.Secondary Objective(s): - To investigate neurodevelopmental outcom eat school age on several developmental…
To enhance our knowledge of the molecular nature, induction and regulation of the autoantibody and B cell response involved in/responsible for the induction of VITT
Gain insight into the health and health-related factors in adults with intellectual disabilities.
Primary objective: Development of a normal tissue complication probability (NTCP) model for hypothalamic dysfunction (for severe hypothalamic dysfunction, named hypothalamic syndrome) in childhood brain tumor survivors, incorporating cranial…
To determine the real world response to standard of care CAR T-cell therapy, in order to better understand the intrinsic and extrinsic factors related to treatment success or failure.
To investigate the effect of multiple sessions of whole body NMES, with or without consecutive protein intake, on muscle protein synthesis.
Primary Objective: To determine how exposure to +5Gz forces affects small airway function when breathing ambient air (21% oxygen) and oxygen enriched air (60% oxygen) , without the breathing component of the AGSMSecondary Objective: To explore the…
The overall aim of the Ageinglines cohort study is to better understand the biological ageing process and its association with the onset (pre)frailty and well-being in later life and to identify targets for delaying the biological ageing process…
Primary objective is to investigate if the sEMG signal derived from the SERA device has an association with weaning failure, defined as an unsuccessful SBT, or extubation failure, defined as the need for re-intubation for respiratory reasons within…
Optimization of OE-MRI protocols and workflows to prepare for hypoxia mapping and quantification on an MR-linac
The objective is to initiate a hiPSC-resource from 10 genotyped participants of the Doetinchem Cohort Study, with a characterized life course history of up to 35 years during their adult life, with the intent to deploy mechanistic and causality…
Primary RQ: 1) Is time spent in daylight associated with better mood in recently remitted depression patients? Secondary RQ*s: 2) Is the association dependent on age, sex, circadian rhythms and chronotype? 3) Is the association dependent on timing…
The aim of this project is to unravel whether BPD after the neonatal period is a chronic inflammatory disease, and if markers of inflammation and/or oxidative stress are related to pulmonary morbidity in patients with BPD. Based on these findings,…
Our study aims to identify unique Metabotypes among individuals with overweight at risk of T2DM and assess their response to a 1-year precision dietary macronutrient modulation. The objective is to provide proof-of-concept that this approach…
In this proposal, we will collect samples from both US and international corneal ulcers, identify etiology, AMR, and local host immune response, and correlate with presentation and outcome.Specific Aim 1. Worldwide surveillance of organisms…
To study anti-SARS-CoV-2 antibody-mediated inflammatory responses by macrophages in individuals with obesity.