24 results
The present study will examine how young-onset-dementia patients and their families can be supported in their home environment as long as possible and institutionalisation can be delayed. For this the functioning and care needs of young-onset-…
The main objective of this specific study is to examine to what extend differences in cognitive functioning between people are due to complex interactions between genes and environment.
Using pedigree research in two CVID-families to find clues for genetic testing.
The present study will focus on the consequences of long-term delay of puberty induced by treatment with Decapeptyl-CR. We will investigate the effects of this treatment in regard to brain functioning, brain development, various endocrine, metabolic…
To identify novel childhood cancer-predisposing genes in children.
To investigate the onset and short term natural course of ADD and TMJ hypermobility in children, and to give insight into some related risk factors.
The objective of this study is to identify determinants, to determine the transmissibility and to determine the burden of disease of NT-MRSA and CA-MRSA carriage compared to other typeable MRSA strains in the community.
In the research project proposed here, we assess all important elements of the model in a longitudinal set-up, with four assessments, separated by 6 months. This approach will allow us to study the different hypothesized mechanisms in the…
The key objectives of the performance tests in the present study are:- To test for the effect of performance pressure during intellectual assessment on MZ and DZ twins. - To study how genetic and environmental estimates derived from path models of…
To investigate the occurrence of undiagnosed CHARGE syndrome in patients diagnosed with (atypical) Kallmann syndrome and to define criteria for CHD7 analysis in patients with Kallmann syndrome.
The aim of the current research proposal is to fill a gap in our knowledge of the role of negative thinking in the development of depressive symptoms in children and adolescents. 1. To what extent does stress-reactive rumination, attributional style…
This study observes the immune system of children and adults who have been without a thymus for 3 to 30 years. Our objective is to study the role of the thymus in the developing immune system. In addition this study will give insight in the long…
Cognitive processes and the development of psychopathology in children at risk for anxiety disorders
Goal of the study is to establish evidence on cognitive biases in a high risk population and on the longitudinal impact of such biases. We hypothesize that CPAD*s show biases in their information processing when compared to control children. We…
To detect B-cell differentiation and maturation defects in patients with antibody deficiency syndromes of unknown origin (CVID, SAD), which are predictive for clinical complicationsTo detect and sequence candidate genes in subgroups of patients with…
1. estimate the prevalence of MRSA among calve farmers, their families and relevant co-workers at the calve farm;2. determine potential risk factors for MRSA carriage for these groups3. determine the association between MRSA prevalence and types of…
The objective of the study is to get more insight into the interpretation of multiplex PCR test (which are so sensitive, that falls positive samples due to colonisation, or interpretation problems due to mixed infection may occur) and to expand a…
Identification of genes that are involved in congenital heart defects.
To develop and validate a biomechanical measurement protocol that can assess wrist flexion deformity resulting from a UMN lesion.
The primary oblective of the study is to elucidate all molecular mechanisms leading to coeliac disease.In order to establish the scientific basis for the development of improved diagnostics, novel therapies and safer foods for patients, in the CDC:…
We propose that variation in genes involved in the regulation of motivational behaviour and satiety plays a major role in the development of obesity. We aim to identify these genes using family-based association and linkage analysis in a large…