470 results
Hypothesis: gaseous signaling molecules influence placental vasomotor activity to compensate for hypoxemia. Metabolites of these vasoactive molecules can be found in the blood and urine and can indicate whether this (compensatory) mechanism is used…
The objective of this study is to obtain physiological data on lung aeration during pulmonary transition in newborn infants.
Primary Objective: 1. To determine whether there is a difference in arterial wall inflammation between well-controlled and poorly-controlled type 1 diabetes patients2. To determine whether patients with type 1 diabetes have a higher level of…
Primary Objective: To gain more insight in the genetic susceptibility for AIH. For this we will study the presence of candidate genes in AIH patients, study genetic similarities with other auto-immune diseases and perform a whole genome association…
Primary Objective: 1. Determine if assessment of mucosal and serological immunological characteristics in combination with clinical indicators of disease behaviour and response to therapy can identify immune-based phenotypes with implications for…
To establish whether or not DPD deficient patients suffer from an altered white blood cell homeostasis or function, in particular of B or T lymphocytes.
To unravel the cause(s) of the FH phenotype in patients with no mutations in well-established lipid genes (LDLR, APOB, PCSK9).
To identify novel childhood osteosarcoma predisposing genes.
Investigating the molecular and phenotypic differences of iPSCs established from skin fibroblasts of discordant MZ BWS twin pairs.
To assess the effects of marathon running on changes in cardiac and skeletal muscle structure and function using state of the art MRI techniques, ultra-sensitive biomarker assays and a high resolution 64-lead electrocardiogram.
To prevent vessel damage of the radial artery by using the Cordis Railway sheathless guiding catheter system.
The main objective of this study is to investigate whether a long lasting pro-inflammatory phenotype, the characteristic of trained immunity, is present in circulating monocytes of patients with severe periodontal disease and whether this correlates…
to determine if there is an alternative mechanism for urine acidification in men in response to NH4Cl other than that through ENaC
To study the pharmacokinetics of non-reactive labelled histidine (L-HISTIDINE:HCL:H2O (D5, 98%; 15N3,98%) and the effect on intestinal imidazole propionate (IP)production in small intestine vs colon in healthy controls, metabolic syndrome and DM2…
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with CADASIL, relative to controls.
The objectives are to study short-term changes in lung function, exhaled NO, respiratory symptoms and bronchodilator medication use in association with short-term changes in UFP in general and UFP from aircraft emissions specifically in children…
The purpose of this study is to find out which common problems occur in the HME patient population. Furthermore the study will investigate which factors are associated with the observed problems. This is barely investigated in the current literature…
To investigate the impact of (a disrupted) circadian rhythm on food preferences and chemosensory perception.
In this study we use a unique paradigm which can be used to examine both high-level (serial dependence) effects as low-level (adaptation) effects. By doing so we hope to resolve the discrepancy in the previous findings. We expect that low-level…
Area of interest (study setting): Specific aims:Transient triggers and chronic riskfactors (case-crossover and casecontrol)(1) To investigate frequency and strength of association between transient physical andpsychological triggers and early-onset…