50 results
We would like to eludicate the role of dopamine on glucose metabolism.
We aim to establish whether our judgment of *misperception* is really doing justice to the condition paradoxical insomniacs suffer from. We should keep in mind that our present definition of sleep, based on the standardized polysomnographic scoring…
To establish whether carriers of LMNA mutations have a hypercoagulable state compared to non-affected family members.
To investigate the state of the endothelial glycocalyx in cancer patients and determine the effect of chemotherapy on this layer.
The aim of this study is to improve insight in potentially genetic factors contributing to the development of pyloric stenosis.We aim to investigate the association of the COL3A1 gene and pyloric stenosis because of concrete signs in the existing…
The aim o this study is to examine the cause(s) of large increases in weight after lung transplantation; the effect of daily physical activity, daily food intake and resting energy expenditure will be investigated in COPD and lung fibrosis lung…
to evaluate progression of IMT in post-coarctectomy patients in 7 years follow up.
1.To relate activity of the HPA axis to OCD symptoms and prefrontal brain abnormalities, using plasma ACTH and urine cortisol measures.2. To examine the role of nucleus accumbens activity on changes in endogenous glucose production, energy…
To sess the relationship between cerebral perfusion and clinical findings (neurological and neuropsychological) in patients with sickle cell disease.To compare iamging fincdings in children with and without sickle cell disease.
Do high plasma free fatty acids lower central serotonergic responsivity?
This project is the cross-sectional part of a large-scale longitudinal follow-up survey in patients with adult-onset asthma. The objective of this part of the survey is to define different phenotypes of adult onset asthma and to detect risk factors…
The aim of this study is to investigate the bilateral symmetry of the human wrist joint and its clinical applicability. The analysis of the bilateral symmetry of the wrist is of great clinical relevance. If there appears to be a high grade of…
1. To establish the prevalence and prognostic impact of HD-associated LV dysfunction; 2. To identify (clues to) mechanisms/ pathways that are pathophysiologically involved in HD-associated LV function.
The primary objective is to study the effects of GH substitution therapy in adult GH deficient survivors of childhood cancer. Primary endpoints are organ size, renal function and capillary density of the skin.
To investigate the role of different ADAMs (e.g. ADAM10 and ADAM17) in cigarette smoke extract (CSE)-induced production of inflammatory parameters (TGF-* shedding, MUC5AC and IL-8) in primary epithelial cells and compare the effects in cells derived…
In the current study we want to evaluate the triglyceride clearance in a population with EXT-1 and EXT-2 mutations (n=15) and their unaffected family members (n=15). We will perform:* Oral fat loading test (OFLT) to investigate lipid clearance * LPL…
To investigate whether local inflammation in the area of the stomach and gastroenteric anastomosis is a cause of primary DGE.
The primary objective of this study is to unravel mechanisms by which dietary protein (fractions) could influence systolic and diastolic blood pressure in humans.
To determine the role of VWF and ADAMTS13 in the adherence of sickled erythrocytes to vascular endothelium.
To identify patients with TRalpha-1 mutations among adolescents with delayed puberty.