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The influence of Deep Brain Stimulation on the critical elements of cognitive control in Obsessive-Compulsive Disorder Patients.

In the proposed study, we will experimentally elucidate the effect of DBS on various critical dimensions of cognitive control including: the free will experience, instrumental learning, environmental change detection and working memory.

Gut microbiotica composition and postprandial effect on endotoxemia in obese healthy males and obese insulin resistant males

The aim for this study is to investigate feces composition and postprandial effect, as done with oral fat loading test (OFLT), on endotoxemia (e.g. LPS and Ralstonia levels) in plasma as assessed with qPCR.

Multifocal motor neuropathy: a natural history study on prognosis, disease mechanism and new biomarkers.

1.To document natural history in this patient group and to establish which factors put patients at risk for an unfavourable outcome. 2.To determine which factors contribute to (reduced) quality of life (QoL) in patients with MMN.3.To investigate the…

The association between loss of gut wall integrity as measured by ZOnulin and hepatic ischaemia as measured by NIRS and Biliary Atresia development

To confirm that loss of gut wall integrity is associated with the development of biliary atresia and to investigate possible hypoxia in the liver/bile ducts in children with biliary atresia using NIRS

Is CABG-induced vascular inflammation detectable by FDG-PET/CT? A pilot study

To explore FDG-PET/CT to quantify the effect of CABG on inflammation in the arterial wall.

Quantification of trans-intestinal cholesterol excretion in patients with familial hypobetalipoproteinemia

The purpose of the current study is to evaluate the difference in TICE in FHBL-patients as compared to unaffected controls, according to the previously developed stable isotope method with minor modifications (METC 10/092). This way we can prove the…

Identifying genetic determinants of Familial Barrett*s esophagus and adenocarcinoma of the gastro-esophageal junction

The main goals of this study1) To determine the prevalence of BE among first degree relatives of index patients in families that fulfil criteria for familial BE/adenocarcinoma of the GEJ2) Collect tissues of the index patients and all first degree…

Neural Structure and Function in Tourette Syndrome: distinguishing neural structure and function in Tourette Syndrome from attention-deficit/hyperactivity disorder.

The aim of the study is to acquire MRI, genetic and neuropsychological data on TS subjects. We aim to do this for the purpose of then identifying brain (1) structural, (2) functional and (3) connectivity abnormality differences, and (4)…

Evaluation of the use of biomarker levels in dried blood spots as a measurement tool for disease severity in patients with atopic dermatitis (AD) and psoriasis.

to investigate whether the levels of a panel of biomarkers in dried blood spots can be used as a disease severity measurement tool in patients with AD, treated with topical steroids.

Follow-up of patients with idiopathic ventricular fibrillation, the FU-IVF study.

To phenotype and genotype the population of patients with IVF in our cohort, and to find alternative diagnoses as a cause of the event of VF.

Effects of timing of hypercaloric snacking diets on metabolism and brain

To determine the effects of hypercaloric HFHS snacking in the morning or evening on insulin sensitivity and serotonin function in the diencephalon.