38 results
1. Immunology and Pathology:To determine the immune response of patients with simple and complex appendicitis in order to identify markers which distinguish between simple and complex appendicitis.2.Clinical and Imaging:To analyze the differences in…
1. To identify genetic variants associated with an increased risk of ASD using different genetic models (dominant, recessive, interaction).2. To determine the relationship between different genetic variants and the associated neuropsychiatric ASD…
The primary objective of the current study is to (further) investigate the role of reward and punishment sensitivity in Anorexia Nervosa and obesity by examining general and disorder-specific appetitive and aversive biases. The secondary objective…
The main objective of this study is to identify rare, high-penetrance germline mutations predisposing to familial and/or early onset UBC.
18-22 YEAR OLD MALES WIHT A NORMAL WEIGHTExamine the possible attenuating cardiometabolic health effects of (A) hourly, 10-min standing interruptions, when compared to a single bout of prolonged sitting, and (B) sitting on a stability ball, when…
To study sensory processing and hyperexcitability in children with ASD and epilepsy using neurophysiological measurements (EEG/ERP).
De lnternational CIDP Outcome Study (ICOS) aims to describe in detail the variation in clinical and electrophysiological subtypes, current practice of treatment, clinical course and outcom in CIDP. The second objective is to define the clinical and…
To obtain intermittent buccal and continuous sublingual microcirculatory profiles by sidestream dark-field imaging before and after induction of propofol by non-invasive diagnostics in infants and children.
In this study one of the goals is to compare 7 tesla MRI with 3 tesla MRI in terms of lesion detection in epilepsy patients and depiction of specific dysplasia-related imaging characteristics. Furthermore, resected tissue will be scanned ex-vivo at…
The purpose of this study is to test whether perceptual expectations modulate V1 activity consistent with *hypo-priors* in autistic individuals.
To elucidate the molecular mechanisms underlying renal disease that lead to chronic kidney disease. To validate pathogenic variations in functional in vivo models.
The objective of the study is to map in a standardized way the phenotype of carriers with known LHON mutations. We want to study the natural course of persons with LHON mutations by examining patients several times. Further, we want to study a…
1. The application of 4D flow MR imaging to analyse blood flow patterns (flow angle, flow asymmetry), regional vessel wall parameters (regional wall shear stress, vessel wall thickness) and pulsed-wave velocity in neoaortic root, carotid artery and…
To determine the variability of cognitive features in NF1 and TSC in the absence of genetic variability.
The primary aim is to characterize mucosal immune responses in concomitant PSC and IBD. Secondary objectives are (1) to identify phenotype and function of the mucosal immune responses in peripheral blood, liver and intestinal biopsies of patients…
This study had two objectives:1. which factors determine outcome of treatment of children with functional childhood constipation referred to the outpatient clinic of multidisciplinary treatment clinics in the Netherlands;2. which factors can be…
Primary Objective(s): - To determine the relation between CPET and pulmonary and muscular performance in patients with Tetralogy of Fallot.- To study the effect of previous lateral thoracotomy on pulmonary function and exercise.Secondary Objective(s…
Cognition in patients with Juvenile Myoclonus Epilepsy and their first degree healthy family members
Key Question: What is the level of cognitive performance in healthy siblings of juvenile myoclonic epilepsy patients compared to that of patients with juvenile myoclonic epilepsy?
We aim to to record heart rate patterns during seizures with miniaturized wearable EKG-monitors in a large cohort of DS
(also see: C1. Protocol, page 12, paragraph 2)Primary Objective:Improving risk assessment of acute porphyric attacks and complications in patients with acute porphyria.Secondary Objectives: 1. Obtain and describe basic demographics and statistics,…