257 results
Primary: To further characterize a cohort of older patients with bipolar disorder, including clinical features, cognition, social functioning, need of care, family history and inflammation markers.Secondary: To investigate the effects of aging on…
To investigate associations between IBD severity, ASCA titer, microbiota composition and C. albicans strains present in feces.
to identify novel molecular pathways resulting in premature atherosclerosis (PAS) in families where the traditional risk factors are not present / near absent.
To compare the level of the sIL-2R between patients who are referred to the Center for Pain Medicine with a suspicion of CRPS but do not fulfill the new IASP Clinical Diagnostic Criteria for CRPS and those who do fulfill the new IASP Clinical…
Primary objective: To investigate whether AS patients have increased signs of microvascular abnormalities of the retina, compared with healthy controls.Secondary objectives: to investigate:1. the peripheral microvascular function in AS patients,…
To prospectively study the effect of salt restriction on the rise in blood pressure in response to anti-cancer treatment with the VEGF inhibitor sunitinib and regorafenib.
To gain a better understanding of NET formation by human neutrophils and the molecular mechanisms underlying this process.We would like to gain insight in:* The differences in NET formation upon the exposure of neutrophils to different stimuli.* The…
Primary goal:To provide an overview of long term effects (neurocognitive, behavioral and learning problems) in children with MTHI and to identify specific risk groups with a higher prevalence of more serious problems. This knowledge can contribute…
To deliver proof of concept that antifungal prophylaxis with posaconazole in addition to standard of care (SOC) can reduce the incidence of IAA in ICU patients with severe influenza, in comparison with SOC alone.To assess differences in cytokine…
To gain insight into the biological pathways that are influenced by the CEEx30/31 mutations.
Primary Objective: To investigate diastolic LV dysfunction before and after 6 months anti-inflammatory treatment with TNF blockers in patients with RA, assessed by exercise-stress echocardiography.Secondary Objective: To investigate whether systolic…
To examine the presence of structural and functional brain changes in glaucoma patients. Specifically, we are interested in the presence of glaucomatous functional brain changes that are beyond those that can be explained on the basis of propagated…
1) test the hypothesis that there is an age-associated decline in proprioception in asymptomatic participants2) assess the reproducibility and repeatability of the measuring protocol for proprioception.
This pilot prospective cohort study is designed to provide feasibility data for a large global study that will critically evaluate the impact of sport activity and FAI development during the critical phase of hip maturation.Primary Feasibility…
The main objective is to validate serum calcification propensity as a read-out for vascular calcification and the secondary objective is to identify determinants of vascular calcification (progression).
To study PsO patients in the outpatient dermatology clinic in order to 1) to compare the sensitivity and specificity of the easy to use questionnaire: the Psoriasis Epidemiology Screening Tool (PEST) and ultrasonography in identifying PsO patients…
To study the effect of WF Fiber on insulin resistance and (continuous) glucose metabolism and potential underlying mechanisms, body weight and waist circumference, microbiota composition and fasting GLP1/PYY/SCFA, in subjects with pre-diabetes.
1. To establish optimized and standardized approaches for the isolation and characterization of BOECs in control and diabetic patients.2. To test whether the phenotype of BOECs cultured from blood of diabetic patients are significantly different…
Identify molecular differences in carcinogenesis of LSCC between younger and elderly patients through an integrated proteogenomic analysis of laryngeal tissue biopsies that could optimize personalized treatment of elderly patients in particular.
To investigate the role of the dopaminergic system in reward discounting and reward anticipation in ADHD and comorbid disorders. The study investigates the following question: Do patients with ADHD without comorbidity differ from those with ADHD and…