To compare the level of the sIL-2R between patients who are referred to the Center for Pain Medicine with a suspicion of CRPS but do not fulfill the new IASP Clinical Diagnostic Criteria for CRPS and those who do fulfill the new IASP Clinical…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Complex Regionaal Pijn Syndroom.
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is the blood sIL-2R level between patients diagnosed
with CRPS and the patients who are not diagnosed with CRPS.
Secondary outcome
Association between the sIL-2R level and CRPS severity score.
Background summary
The role of the immune system and specifically T-cells in the pathophysiology
of Complex Regional Pain Syndrome (CRPS) is still unknown. Bharwani et al.,
2017, showed an elevated level of sIL-2R in CRPS patients vs healthy controls.
This suggests increased T-cell activation in patients with CRPS. Further, the
sIL-2R seems to be a good discriminator between CRPS patients and healthy
controls with a sensitivity of 90% and a specificity of 89.5%. This finding
warrants further investigation into the role of T-cells in pathophysiology of
CRPS. One limitation of the previous study was that the control group consisted
of healthy blood bank donors with no history of chronic pain. It would be
interesting to study the difference in sIL-2R level between CRPS patients and
chronic pain patients without CRPS. This would increase the validity and
consequently the diagnostic value of this marker in the diagnosis of CRPS.
Study objective
To compare the level of the sIL-2R between patients who are referred to the
Center for Pain Medicine with a suspicion of CRPS but do not fulfill the new
IASP Clinical Diagnostic Criteria for CRPS and those who do fulfill the new
IASP Clinical Diagnostic Criteria for CRPS and thus are diagnosed with CRPS.
Study design
Cross sectional cohort study
Study burden and risks
This study carries a negligible risk related to venepuncture.
's Gravendijkwal 230
Rotterdam 3000CA
NL
's Gravendijkwal 230
Rotterdam 3000CA
NL
Listed location countries
Age
Inclusion criteria
Patients who are referred to the Center for Pain Medicine with a suspicion of CRPS.
Age * 18 years.
Only one limb is affected.
Exclusion criteria
History of an auto-inflammatory or autoimmune disease.
Current treatment with immunomodulating medication or treatment within the last 6 months.
Ill at the time of visit or recently been ill in the past two weeks.
Knowledge of or confirmed pregnancy.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL62737.078.17 |
| OMON | NL-OMON20955 |