No registrations found.
ID
Source
Brief title
Health condition
Complex Regional Pain Syndrome
Sponsors and support
Department of Anesthesiology
Erasmus MC University Medical Center Rotterdam
Intervention
Outcome measures
Primary outcome
sIL-2R level
Secondary outcome
CRPS severity score
Background summary
Rationale: the role of the immune system and specifically T-cells in the pathophysiology of Complex Regional Pain Syndrome (CRPS) is still unknown. Bharwani et al., 2017, showed an elevated level of the sIL-2R in CRPS patients vs healthy controls. This suggests increased T-cell activation in patients with CRPS. Further, the sIL-2R seems to be a good discriminator between CRPS patients and healthy controls with a sensitivity of 90% and a specificity of 89.5%. This finding warrants further investigation into the role of T-cells in the pathophysiology of CRPS. One limitation of the previous study was that the control group consisted of healthy blood bank donors with no history of chronic pain. It would be interesting to study the difference in sIL-2R level between CRPS patients and chronic pain patients without CRPS. This would increase the validity and consequently the diagnostic value of this marker in the diagnosis of CRPS.
Objective: to compare the level of the sIL-2R between patients who are referred to our Center for Pain Medicine with a suspicion of CRPS but do not fulfil the new IASP Clinical Diagnostic Criteria for CRPS and those who do fulfil the new IASP Clinical Diagnostic Criteria for CRPS and thus are diagnosed with CRPS.
Study design: cross sectional cohort study.
Study population: the study sample consists of adult patients who are referred to the Center for Pain Medicine at Erasmus MC University Medical Center Rotterdam with a suspicion of CRPS.
Main study parameters/endpoints: the main study parameter is the blood sIL-2R level between patients diagnosed with CRPS and the patients who are not.
Study design
Day of visit at outpatient clinic
Intervention
Not applicable
Inclusion criteria
The study sample consists of adult patients who are referred to the Center for Pain Medicine with a suspicion of CRPS.
In order to be eligible to participate in this study, the patient must meet all of the following criteria:
- Age ≥ 18 years.
- Only one limb is affected.
Exclusion criteria
A patient who meets any of the following criteria will be excluded from
participation in this study:
- History of an auto-inflammatory or autoimmune disease.
- Current treatment with immunomodulating medication or treatment within the last 6 months.
- Ill in the past two weeks or at the time of visit.
- Knowledge of or confirmed pregnancy.
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7267 |
| NTR-old | NTR7465 |
| CCMO | NL62737.078.17 |
| OMON | NL-OMON44506 |