95 results
To assess the effect of dietary lipids on the small intestinal microbiome in humans (proof-of-concept), the primary objective is to measure production of microbiota-derived lipid metabolites in the human small intestine after consumption of a high-…
Primary Objective:1)To examine whether exposure to bullying victimization in adolescence is associated with the CTRA transcriptome profile(increased pro-inflammatory gene expression and decreased antiviral and antibody-related gene expression) in…
Our primary objective is to determine if there are (gain-of-function) mutations of Nav1.7 and Nav1.8 in patients with ACNES.Our secondary objective is to see if there is a difference between patients with and without mutations, and:- Known…
Primary objectives: - To examine how environmental exposures influence the prevalence, 5-year incidence and progression of cardiometabolic and chronic respiratory disease in the general population. - To determine the mediation effect of lifestyle…
To demonstrate the ability of using non-invasive 31P-MRS to monitor changes of in vivo markers of mitochondrial function in skeletal and cardiac muscles (i.e., skeletal muscle PCr recovery rate constant and cardiac PCr/ATP ratio) in DLBCL patients…
To overcome the heterogeneity dilemma that hampers drug development, we propose a translational within-subject approach that integrates clinical, pathological, and molecular/cellular data of induced pluripotent stem cells (iPSC) derived neurons and…
To determine the relationship between tissue immune responses and the clinical course of mycobacterial infections.
Primary objective: To assess the effect of ICI on progression of coronary non-calcified plaque volume and ICI-related cardiovascular events by measuring differences in plaque burden using repeated CCTA.Secondary objectives:- To evaluate the relation…
Primary objective: To improve outcome prediction in sFGR by developing a prediction model at the time of sFGR diagnosis and by evaluating specific ultrasound parameters throughout the pregnancy. Secondary objectives: - To increase our knowledge of…
To longitudinally evaluate the substantial differences in anatomical changes in the spine during adolescent growth in girls, at increased risk for scoliosis development, and in adolescent 22q11.2DS patients, that do and do not develop AIS.
The aim of the study is to map the changes that occur in breast tissue composition during pregnancy, lactation and post-lactational involution. The secondary aims are to:• validate the performance of diffuse optical spectroscopic imaging (DOSI)…
Primary objective:- To evaluate the safety and tolerability of colonisation with non-toxigenic C. difficile.- To establish the effective protocol to obtain colonisation with non-toxigenic C. difficile in the majority of subjects.Secondary objective…
In this study we try to elucidate the possible contribution of inflammation of the joint mucosa to the development of knee osteoarthritis. If we understand more about the inflammatory processes in the synovium that are important in further…
Unravel the working of the immune system in South Asians, specifically the monocytes. We will also study whether the release of incretin hormones (GLP-1 and GIP) following a meal is lower in South Asians compared to Europids. The latter we will…
a) Determine whether acute cardiac CT has a higher probability of diagnosing LA thrombi compared to TEE or repeated cardiac CT in the subacute phase of ischemic stroke by assessing the rate at which LA thrombi dissolve in the first days after…
Generate prospective follow-up data to increase our understanding of this rare disease.
The first aim is to determine an objective acoustic measure to define SMS by comparing acoustic features of probe words to a perceptual score of speech motor movement characteristics and stuttering frequency judged by the expert (i.e., the current…
Primary:- Investigate the feasibility of examining fetal and neonatal brain developmental trajectories in the fetus and neonate with at least one parent with SMI in the mood-psychosis spectrum (vs. parents without SMI) using MRI.- Acquire…
Test the effect of five different sodium- and potassium salts in patients with chronic kidney disease.
Primary objective: Compare characteristics of endothelium from older individuals with or without previous unprovoked VTE.Secondary objectives: 1) Determine the blood plasma proteome between the different groups and 2) to evaluate the prothrombotic…