98 results
The aim of this experiment is to determine the differential effects of noradrenaline and cortisol on memory accuracy versus generalization and to investigate the divergent effects of these stress mediators on the neural mechanisms underlying the…
To quantify fructose that escapes the portal circulation and appears in the systemic circulation, by measuring serum fructose using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) within 150 minutes following intake of…
Primary Objective: The primary objective of this study is to develop and validate an energy expenditure estimation and physical activity classification algorithm based on wearable sensors. To do so the relevant signals contributing to the…
Primary:-To identify subjects with documented history of myocardial infarction (MI) and/or percutaneous coronary intervention (PCI) and lipoprotein(a) (Lp[a]) levels >=90 mg/dL or Lp(a) >=200 nmol/LSecondary:-Evaluate the distribution…
To evaluate the quality of cold snare biopsies specimens of duodenal mucosa tissue in patients undergoing an upper gastrointestinal interventional endoscopy under deep sedation to improve histological assessment of duodenal mucosa in general and…
In the current study we aim to measure the postprandial amino acid uptake kinetics of barley rice protein, and compare this to pea protein. A benchmark protein (whey) will be included for comparability of amino acid uptake of different protein…
Primary objective 1) To evaluate the usability of the total viQtor solution applied and used 24/7 in clinical practice.This includes the ease of use and/or usability of:the wearable, charger and armband by the primary participants/usersthe *care…
To understand the mechanism of action of OA for the treatment of de novo, severely calcified coronary lesions prior to stent placement using optical coherence tomography (OCT) and to assess stent expansion, based on OCT derived minimal stent area (…
Assess amyloid beta clearance from CSF to serum in response to HFCWO in healthy volunteers:- Change from baseline in amyloid beta 40 (ng/ml) in CSFAssess endogenous protein biomarker clearance from CSF to serum in response to HFCWO in healthy…
The primary objective of the second part of the study, which is the focus of this application, is to perform a comparative analysis of the cognitive profile and MRI outcomes of DMD/BMD patients.
The primary objective of this study is to establish whether cerebellar patient populations can adapt and learn to maintain standing balance when sensory-motor relationships of balance are modified. By comparing patient behavior with age-matched…
To assess the acute impact of passive heat treatment on the post-prandial glycaemic response during an OGTT in T2DM patients.
To obtain an estimate of the prevalence of chlamydia and gonorrhoea among men and women aged 16.5 to 34 years.
Primary objective:- To identify (a combined set of) clinical and non-clinical markers most sensitive to disease progression in Dtuch SCA7 mutation carriers.Secondary objectives:- To quantify the annual change in disease-relevant clinical scales and…
We aim to illustrate the relationship between early-life-adversity and emotional memory performance, and whether schema related neural activity during encoding and retrieval will contribute to the negative memory biases.
This study aims to determine feasibility of providing and following ICU discharged patient with smart technology for 3 months after hospital discharge from a general ward of the Leiden University Medical Centre. If proven successful, home monitoring…
The aim of the study is two-fold: (i) to test the neural basis of domain-specific aspects of wellbeing among adolescents and adults, and (ii) to examine how individual differences in neural emotional reactivity (based on previously acquired data)…
This study has several objectives, in different (subsequent) study phases:• A1. Optimize and validate the technology of the VD to reach non-inferiority• B1. Demonstrate non-inferior performance and safety of the VD, for CE marking• B2. Demonstrate…
The primary objective of this study is to investigate if the use of Heli-FX EndoAnchors in conjunction with placement of aortic stent grafts under instructions foruse (IFU) conditions in aneurysms with a wide neck is superior to treatment with…
This traditional feasibility study intends to inform a future pivotal trial in the following two ways. Firstly, it aims to evaluate the potential of neural health metrics triggered by FMS, to predict the implant recipient*s auditory performance -…