118 results
1. Assessment of sensitivity of several outcome measures in muscle force and function in Duchenne muscular dystrophy2. Assessment of reproducability of different outcome measures3. Assessment of clinical relevance of measured change over time in…
To include Dutch subjects in a Canadian study to establish the frequency of intergenerational CAG size changes for individuals with an intermediate allele (27-35 CAG) for Huntington disease. This will allow us to understand the evolution of HD…
The primary objective is to examine whether a combined treatment with rivastigmine (cholinesterase inhibitor) and citalopram (selective serotonin re-uptake inhibitor) will improve memory as compared to the treatment with either rivastigmine or…
We will perform pilot studies for three different experiments:A) Finding two congruent combinations of aroma and base products that are either associated with high energy dense products or low energy dense products, which we can use in the SenSation…
The main objective is to elucidate the acute effects of an oral intake of either saturated, monounsaturated or polyunsaturated fatty acids on PBMC whole genome expression of obese and type 2 diabetic obese subjects. Secondary objectives are to…
The primary objective is to investigate how autistic adolescents integrate multisensory information within the temporal domain. The following assessments will be made:Experiment 1: Perception of audiovisual temporal synchrony (an audiovisual…
The objective of this study is threefold. First, to investigate neural correlates of cognitive-emotional processing in an ARMS sample, i.e. help-seeking young people with an at-risk mental state (this will be addressed in the base-line measurement…
Primary objective:To determine the hepcidin levels before, 2, 4, 8 and 24 hours after the administration of anti-IL-6R in patients with RA.Secondary objective:To determine the levels of Iron, transferrin , (calculation of transferrin saturation),…
To find out whether T4 treatment of Down syndrome newborns until the age of 2 years compared with placebo treatment results in better cognitive or motor development at the age of 10 years and 6-8 months, and whether it is safe with regard to nerve…
To study the role of central insulin on glucose metabolism.
In this study we intend to give the label "deuterium" to individuals as heavy water, to determine the turnover parameters of diverse leukocyte populations in health (young adults, healthy seniors of 60 years and older, healthy individuals…
a) To investigate the differences in adipokines and inflammatory markers between obese and normal weight children; b) to study these differences over age, and c) to correlate adipokine/inflammatory marker profiles to clinical parameters for obesity…
The aim of this project is to improve dietary intake assessment using a novel technique, compare it with the existing methodology and validate it against total energy expenditure.a. Improve dietary intake assessment using a 7-day food record in…
Objective of this study is to determine the turnover of leukocyte populations in health (young, old) and how this compares to situations in which the immune system is disturbed ((HIV-1 infection, HSCT, thymectomy).
The primary objective of the proposed study is to gain insight in the underlying neural mechanisms by which frontal cortical activation patterns are established, and its implications for human aggressive behaviour. The proposed approach aims to…
ObjectiveThe overall goal of this project is to identify the specific genomic markers associated with severe anthracycline-induced cardiotoxicity to be able to identify high-risk patients. The specific objective of this proposal To validate and…
Identifying factors that are involved in the way social support is experienced by the patient when confronted with cancer.
What is the difference in fractional cholesterol absorption, measured by means of the dual isotope method, between mildly hypercholesterolemic subjects with high plasma campesterol/TC ratios compared to subjects with low plasma campesterol/TC ratios…
Primary objective 1) To determine how modulating the perceived healthiness of a food alters the neural response to pictures of food packagesSecondary objectives1) To determine how modulating the perceived healthiness of a food alters the skin…