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Comparing food-induced gut microbiome shifts in vitro and in vivo

To support the validity of an in vitro colonic fermentation system, by demonstrating that changes in gut microbiota composition and functionality/metabolism, induced by prebiotics in the in vitro Microcolon model, are mimicking the changes that are…

Seroprevalence Study of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV) in Patients with Plakophilin 2 (PKP2)-associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

PrimaryInvestigate the seroprevalence of pre-existing antibodies to AAV in patients with PKP2-associated ARVCSecondaryTo characterize the burden of illness in patients with pathogenic or likely pathogenic PKP2 mutationsTo characterize arrhythmic…

Health -related Fitness and Motor Skill Intervention in Children with Developmental Coordination Disorder (DCD)

The aim of this study is to evaluate two training protocols that both intend to train children with motor coordination problems, such as DCD and increase the level of motor skills, and fitness that falls within the normal range of participating in a…

Clinical Performance Study Plan for Ki-67 IHC MIB-1 pharmDx (Dako Omnis) on Early Breast Cancer Specimens used to identify subjects for enrolment in AstraZeneca*s Phase III CAMBRIA-1 trial (D8531C00002)

This clinical performance study will evaluate the effectiveness of the Ki 67 IHC MIB-1 pharmDx (Dako Omnis) to identify estrogen receptor (ER)+/human epidermal growth factor receptor 2 (HER2)- early breast cancer patients whose tumours score Ki-67…

A Natural History Study of Exocrine Pancreatic
Function in Infants with Cystic Fibrosis Less Than
12 Months of Age

To characterize the natural history of exocrine pancreatic function as measured by FE-1 in infants with CF <12 months of age