134 results
Primary objective: To investigate the safety, tolerability and infectivity of male Schistosoma mansoni cercariae in healthy Schistosoma-naïve volunteers. Exploratory objectives: To investigate the kinetics of controlled infection with male…
Primary objectives* To correlate social, physical, and biometric activity of FSHD patients with the FSHD Clinical Score (Lamperti) and the Timed Up-and-Go Test.* To evaluate the feasibility and subjective burden of remote monitoring in FSHD patients…
To determine the frequency of R5-tropic N332+ viral isolates present within the latent reservoir while on suppressive ART.
To determine the local and systemic immune profile, with emphasis on T lymphocytes, in pancreatic cancer patients; and monitor how these immune profiles are affected by treatment for individual patients.
The primary study objective is to assess protein intake at the end of the first treatment cycle in patients with CRC or NSCLC undergoing first line treatment with chemo-, concurrent chemoradio- or immunotherapy who are receiving…
Primary objective:To compare the proportion of participants who make at least one critical error after reading the section on inhaler use in the patient information leaflets (PILs) for ELLIPTA and BREEZHALER inhalersSecondary Objectives:To compare…
To assess the spatial topographical representation of anger and behavioural inhibition in the cerebellum.
To explore, whether markers of mitochondrial dysfunction measured in isolated PBMCs or immune cell subpopulations differ between subjects with mitochondrial disorders and cardiomyopathy and healthy volunteers.
Objective: we aim to achieve a better understanding of the effect of age on NPE and MRI changes in the adult DMD patients and hypothesize that the cerebral growth curves have an altered trajectory.
The primary objective is to assess whether the insulin-stimulated glucose uptake in quadriceps muscle can be improved through 4 weeks of supplementation of clenbuterol.
In this study, we aim to prove a double dissociation between the contribution of dopamine and norepinephrine during the acute stress response.
We aim to establish the difference in immunological function of HNSCC patients undergoing (chemo)radiation with protons versus photons. These preliminary data are required to follow-up with larger studies to compare the effect of proton (chemo)radio…
The objective of this study is to validate a novel MRS-based method to quantify NAD+ by selectively suppressing the coupled α-ATP spin system, which is overlapping with the NAD+/NADH signals in vivo. For NAD+/NADH quantification to be valuable in…
To demonstrate that combined phMRI/phMRS can characterize the dose-dependent neurometabolic response to S-ketamine.
Primary: To investigate the effect of protein density and texture on gastric emptying of protein-rich solid food. Secondary: To investigate the use of MRI T2 and T1 of gastric content on indicating protein hydrolysis in stomach.
1. To assess serum calcification propensity (T50) in SSc patients compared with healthy age and gender-matched controls; 2. To assess serum T50 in SSc patients with overt calcinosis cutis as compared to age and gender-matched SSc patients without; 3…
To assess achieved immunity against COVID-19 across the different age groups in The Netherlands by testing a representative part of the Dutch population for the presence of SARS-Cov-2 specific antibodies in serum
Primary Objective: We aim to provide a clear phenotype of the immune system in patients with FOXP1 syndrome. Secondary Objectives:We aim to correlate the immunophenotype of patients with FOXP1 syndrome with frequency and type of infections reported…
The main objective of this project is to validate a standardized volume measurement system (using eight in-house 3D printed phantoms) to allow for reliable atrophy measurements in MS, by quantifying between-scanner and within-scanner reproducibility…
Primary Objective: Investigate the effects of nVNS on risk-taking behaviorSecondary Objective(s): Compare observed effect with the effects observed after probiotics interventions using the same task (Chumney et al., 2006; Dantas et al., 2022). These…