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Phenomics and Genomics of Clozapine Pharmacotherapy - New Clozapine Users

To investigate whether methylation patterns/levels and gene expression profiles predict treatment outcome after initiating CLZ.

Predictive biomarkers and the role of the microbiome determining response to antiinflammatory treatment in Inflammatory Bowel Disease (Crohn's disease and ulcerative colitis)

In this project we will investigate biomarkers, cell types and microbiome in biopsies collected from patients with IBD before treatment is started with established therapeutic agents as well as during treatment. The interaction of the microbiome…

MOlecular stool testing for Colorectal CAncer Surveillance

1. To determine the accuracy (i.e. sensitivity, specificity, PPV and NPV) of: a. A molecular stool test, i.e. Cologuard® (Exact Sciences, Madison, WI, USA) consisting of a stool DNA test and an immunochemical assay for human hemoglobin;b. FIT: OC-…

7T MRI of the inner ear and central auditory pathway in sensorineural hearing loss

1. to develop and improve new and existing MR sequences for inner ear imaging at 7T2. to investigate the clinical added value of 7T imaging (in comparison to 3T imaging)

Development and in vivo testing of golden-angle radial sampling dynamic contrast-enhanced MRI (DCE-MRI) in combination with compressed sensing (CS) reconstruction

To compare retrospectively reconstructed, radially sampled contrast-enhanced MR images of the liver with conventionally acquired contrast-enhanced MR images of the liver in terms of Quality of enhancement (QE), overall image quality (IQ), liver edge…

Elucidating the therapeutic mechanism of DBS by simultaneously stimulating and recording from the target brain region.

Our primary objectives are to decode **signatures** of activity from the electrode that might prelude or accompany an OCD attack, by analyzing its activity in an experimental setting and in real-life situations, and to correlate symptom changes with…

Rectal preserving treatment for early rectal cancer. A multi-centred, partially randomised patient preference trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancers.

This study has been transitioned to CTIS with ID 2024-517410-15-01 check the CTIS register for the current data. The aim of this study is to determine the oncological safety, treatment related morbidity, and the functional outcome of local excision…

\u201cA Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Belimumab plus Standard of Care versus Placebo plus Standard of Care in Adult Subjects with Active Lupus Nephritis\u201d (protocol HGS1006-C1121)

* To evaluate the efficacy of belimumab in combination with standard of care in adult subjects with lupus nephritis Class III, IV, or V using the 2003 ISN/RPS criteria. * To assess the safety and tolerability of belimumab plus standard of care…

PVAC GOLD versus Irrigated RF single tip Catheter with Contact FORCE Ablation of the Pulmonary Veins for treatment of drug refractory Symptomatic Paroxysmal and Persistent Atrial Fibrillation

We hypothesize that PVAC GOLD is non-inferior to Single Tip catheter ablation with Contact Force sensor guided by 3-D mapping. This will be tested by comparing procedural characteristics and long term outcome with regard to safety, and effectiveness…

Diet and Aggression: Reducing aggression among chronic psychiatric inpatients through supplementation of multivitamins, minerals and n-3 fatty acids

The main objective in this study is to test the hypothesis that suppletion with vitamins, minerals and n-3 fatty acids in long-term psychiatric inpatients will reduce the number of aggressive incidents.

YOUth babycohort framework protocol

This cohort study aims to explain why some children develop well and others fail to thrive in society. To this purpose, we examine how neurocognitive development mediates the association between developmental changes in biological, child-related and…

A randomized phase II multicenter study to assess the tolerability and efficacy of the addition of ibrutinib to 10-day decitabine in UNFIT (i.e. HCT-CI >= 3) AML and high risk myelodysplasia (MDS) (IPSS-R > 4.5) patients aged >= 66 years.
A study in the frame of the masterprotocol of parallel randomized phase II studies in UNFIT-older AML/high-risk MDS patients

Primary objectives1. To assess in a randomized comparison the effect of Ibrutinib added to 10-day decitabine treatment on the cumulative CR/CRi rate after 3 cycles.Secondary objectives1. To assess the safety and tolerability of Ibrutinib added to 10…

Uptake and biodistribution of 89Zirconium-labeled ipilimumab in ipilimumab treated patients with metastatic melanoma

This study has been transitioned to CTIS with ID 2024-516547-11-00 check the CTIS register for the current data. To assess uptake (visual and quantitative) of 89Zr-ipilimumab in tumor lesions and biodistribution at start of nivolumab/ipilimumab…

A phase 1B multicenter, open-label study to determine the recommended dose and regimen of Durvalumab (MEDI4736) either as monotherapy or in combination with Pomalidomide (POM) with or without low-dose Dexamethasone (DEX) in subjects with relapsed and refractory multiple myeloma (RRMM)

Primary ObjectiveThe primary objective of the study is to determine the recommended dose and regimen ofdurvalumab either as monotherapy or in combination with POM +/- dex in subjects with RRMM.Secondary ObjectivesThe secondary objectives are to:*…

Epicardial and Endocardial mapping of Atrial Fibrillation

to demonstrate persistent atrial fibrillation is associated with endocardial and epicardial dissociation of the heart.

An open-label interventional phase 4 study to evaluate efficacy , safety and mucosal healing of early versus late use of vedolizumab in Crohn's disease: the LOVE-CD study (LOw countries VEdolizumab in CD study)

Primary ObjectiveThe primary objective of this prospective open label study is to assess the ability of vedolizumab to promote clinical, endoscopic and histological remission in patients with active Crohn's disease in an 'early' and a…

A prospective randomized multi-center study comparing endoscopic pneumodilation and per oral endoscopic myotomy (POEM) as treatment of idiopathic achalasia

This study is designed to evaluate which of the two treatment modalities results in the highest success rate after 2 years. Thereafter, follow-up will continue and a similar analysis will be performed 5 years after treatment (and every 5 years…

Randomized, Embedded, Multifactorial, Adaptive Platform trial for Community-Acquired Pneumonia (REMAP-CAP)

This study has been transitioned to CTIS with ID 2023-507889-89-00 check the CTIS register for the current data. REMAP-CAP: The goal of the study is to investigate the best treatment regime for pneumonia patients. For non-pandemic pneumonia (…

A Phase 3, Multicenter, Open-Label Extension Trial of Oral RPC1063 as Therapy for Moderate to Severe Ulcerative Colitis

To evaluate the long-term safety and efficacy of RPC1063 for the treatment of all patients with moderate to severe UCTo evaluate the long-term efficacy of RPC1063 for the treatment of adult patients with moderate to severe UC.

An Open-label, Phase 2 Study of ACP-196 in Subjects with Mantle Cell Lymphoma

The purpose of this study is to evaluate the efficacy, activity, safety, pharmacodynamics and pharmacokinetics of ACP-196 in treating subjects with Mantle Cell Lymphoma (MCL)