2170 results
Primary Objectives• Safety and tolerability• PK of OCA and its conjugates o SD PK Phase: To assess the PK of OCA and its conjugates after a single low dose of OCA on Day 1 and determine subject eligibility for the MD Phase o MD Phase: To assess the…
The main goal of this study is to explore the pattern of physiologic and pathophysiologic cardiac recovery after a preeclamptic pregnancy compared to a normotensive pregnancy, up till 18 months PP.To study the link between placental acute atherosis…
To study whether polytherapy (methotrexate plus sulfasalazine plus hydroxychloroquine) results in more patients with inactive disease and therefore less patients who need treatment with a TNF inhibitor after 6 months of treatment compared to primary…
To investigate the relationship between body composition and parenteral nutrition in children with intestinal failure at 6 months corrected age. The ultimate goil of this study is to optimize the treatment of children with intestinal failure by…
Primary Objective:• To evaluate event-free survival (EFS) after blinatumomab when compared to standard ofcare (SOC) chemotherapySecondary Objective(s):• To evaluate the effect of blinatumomab on overall survival (OS) when compared to SOCchemotherapy…
This study has been transitioned to CTIS with ID 2023-509137-39-00 check the CTIS register for the current data. Primary/dualco-primary. To prospectively investigate whether adjuvant treatment with pembrolizumab after completion of radical surgery (…
To determine if the use of apixaban in patients with SCAF will reduce the incidence of stroke and systemic embolism compared to aspirin.
To increase the major pathological response rate (< 10% vital tumor cells) to neoadjuvant treatment by integrating both trastuzumab and pertuzumab into perioperative chemotherapy for HER-2 positive, resectable gastric cancer.
This cohort study aims to explain why some children develop well and others fail to thrive in society. To this purpose, we examine how neurocognitive development mediates the association between developmental changes in biological, child-related and…
To evaluate whether personalized antihypertensive treatment of mild to moderate gestational hypertension based on maternal hemodynamic profile leads to effective treatment of hypertension with better maternal and neonatal outcome compared to no…
Primary: Phase I: - To characterize the safety and tolerability of MBG453 as a single agent and in combination with PDR001 and to identify recommended doses for future studies. To further investigate the safety and tolerability of different doses of…
The AdaptResponse study is a prospective, randomized, controlled, interventional, single-blinded, multi-center, post-market, global Cardiac Resynchronization Therapy (CRT) in heart failure (HF) clinical study. The purpose of this clinical study is…
Primary objectives- Evaluate the efficacy, defined as PFS, of pomalidomide maintenance plus dexamethasone versus pomalidomide maintenance in patients who responded (>= PR) to the combination of pomalidomide (POM), carfilzomib (CAR) and low…
To investigate whether sweat, tear fluid, saliva and fingermarks can be used as diagnostic tool by determining whether a relation can be found between blood levels and levels found in the four investigated fluids (primary interest: PSA levels,…
The primary objective of the NOVA study is the establishment of a prospective cohort study of patients that initiate cART during the acute infection phase. The secondary objective is to characterize the viro-immunological factors that correlate with…
Measurement and characterization of contractions in a non-pregnant uterus by noninvasive electrophysiological measurements of the uterine muscle activity using a small electrode matrix placed on the abdomen. Simultaneous vaginal ultrasonography…
Primary Objectives1) To compare the Progression Free Survival (PFS) per RECIST 1.1 as assessed by blinded independent central review (BICR) in first line recurrent / metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) subjects, treated…
The current study aims to investigate whether vitamin and mineral status is associated with executive functioning in patients with an eating disorder. Key objectives: 1.To investigate the micronutrient status in patients with an eating disorder…
The study objective is to assess whether positive expectations, induced by verbal suggestions in an open-label design (i.e. knowing about the suggestions), can reduce itch during a short-term validated histamine test.
Primary Objective: To evaluate the effect of treatment with AMG 145, compared with placebo, on the risk for cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization, whichever occurs…