2170 results
The purpose of the current investigation is therefore to prove the short-term equivalence and long-term benefit of the ABSORB scaffold over a Xience in patients at high risk of restenosis or with complex lesion(s).Diabetic substudyTo assess the…
The primary objective is to compare the efficacy of daratumumab when combined with lenalidomide and dexamethasone (DRd) to that of lenalidomide and dexamethasone (Rd), in terms of progression-free survival (PFS) in subjects with newly diagnosed…
This study has been transitioned to CTIS with ID 2023-505981-26-00 check the CTIS register for the current data. Primary Efficacy ObjectiveThe primary efficacy objective of the study is as follows:• To evaluate the efficacy of 16 cycles of…
The two main objectives of the study are:* To assess the efficacy of ADT in treatment naïve patients with recurrent and/or metastatic, androgen receptor (AR) expressing, SGCs. The primary measure of efficacy is Progression-Free Survival (PFS).* To…
The objective of this study is to decrease the number of breast cancer patients receiving overtreatment of the axilla, in order to positively influence the axillary morbidity rate and quality of life. Therefore, we investigate whether the sentinel…
This study has been transitioned to CTIS with ID 2023-509152-33-00 check the CTIS register for the current data. Primary Objectives• To describe the anti-tumor activity and toxicity of commercially available, targeted anti-cancer drugs used for…
Long-term survival in glioblastoma will be addressed in a highly collaborative and comprehensive working program focusing on patient characteristics and (host)- related factors, identification of molecular tumor characteristics, therapy-related…
The aim of this study is to see if there is an association between geriatric screening and outcomes. This could lead to a prediction of clinical outcomes in older patients visiting the hospital, using a mix of routine clinical parameters and…
Primary: To evaluate the antitumor activity of INC280, as measured by overall response rate (ORR) as by a blinded independent review committee, by cohort.Secondary: Duration of response (DOR), ORR and DOR by investigator, time to response (TTR),…
FLUYT: To investigate whether aggressive rehydration with RL during ERCP prevents PEP and will be cost-effective.FLUYT-2-PDS: To investigate if PDS placement further reduce the risk of the development of PEP in patients with unintended PD-wire…
This study has been transitioned to CTIS with ID 2024-511348-25-00 check the CTIS register for the current data. Part 1: To evaluate the efficacy and safety of imetelstat in transfusion dependent subjects with low or intermediate-1 risk MDS that is…
The purpose of this study is to find out if treatment with Nivolumab monotherapy will improve recurrence-free survival (RFS) when compared to Ipilimumab monotherapy in subjects with high risk for recurrence, completely resected Stage III and Stage…
This study has been transitioned to CTIS with ID 2024-516078-31-00 check the CTIS register for the current data. The objective of rEECur is to identify the optimum systemic anticancer regimen for recurrent and refractory Ewing sarcoma based on the…
We address two primary objectives: 1.) To determine whether (awake) surgery on patients with a brain tumor or epilepsy allows for HD-ECoG data collection of adequate quality to address research questions on brain function. In other words, we want to…
A) To test if the EMDR addiction protocol by Hornsveld and Markus (2014), as an intervention, will lead to a reduction of deviant sexual arousal in exhibitionists, within four sessionsB) To test if the treatment effect is stableC) To test if the…
The primary objective of the present study is to assess the involvement of the duodenal TRPV-1 neuropeptide pathway in symptom perception in FD patients compared to healthy controls. The present study has several secondary objectives with regard to…
Primary objective is to analyse vasoreactivity of the vascular system of patients with and without heart failure, in and ex vivo. Secondary objectives are to identify signal transduction pathways associated with the altered vasoreactivity in this…
1. To investigate the optimal time interval for colonoscopy surveillance in patients with low-risk and high-risk adenomas (EPoS I trial and EPoS II trial); 2. To evaluate the yield of surveillance in patients with clinically relevant serrated polyps…
To investigate the performance of indirect glass ceramic and direct composite endocrowns in the restoration of severe structurally compromised endodontically treated molar teeth.
This study aims to evaluate the impact of UAE on Quality of life (QOL) in comparison to hysterectomy in adenomyosis patients. A cost-effectiveness study will be part of the trial as well as a cohort hysterectomy group to clearify imaging and…