2170 results
This proposal will investigate how and which immunosuppressive agents affect the innate immune response against infection. Understanding the impact of immunosuppressive agents on TLR-signaling and TLR-control may be a new focus for the development…
Overall Objective: To define the properties of whey, casein, milk protein, as well as soy protein with and without additional leucine to augment post-exercise muscle protein synthesis when co-ingested with a carbohydrate containing recovery drink.…
The aim of this study is to explore the efficacy, effectivity and costeffectivity of financial incentives for the promotion of physical activity in the health care setting.
Primary objective: To investigate the health benefits of WGW on cardiovascular/ cardio-metabolic health by means of applying a mixed meal challenge. Secondary objective(s): To investigate the health benefits of WGW on liver- and adipose tissue…
Objective: non-inferiority in fixation of the SL-PLUS MIA compared to the traditional SL-Plus stem and superiority of the SL-PLUS MIA in terms of bone and muscle preservation and thereby increased patient satisfaction and outcome as measured by PROM…
To evaluate the feasibility and safety of selective intracoronary hypothermia in acute myocardial infarction
To understand the interrelations between muscle related parameters (muscle mass, muscle strength, physical performance), energy expenditure (actual physical activity and basal metabolic rate), and nutritional status (energy intake and protein status…
What is the effect of Philips Airfloss Ultra plus Listerine Cool Mint compared to dental floss after a healing of experimental induced gingivitis as evaluated with the Bleeding on Marginal Probing (BOMP) index in a group of systemically healthy…
Our main objective is to evaluate and compare appliance of Endobon® Xenograft Granules (Biomet 3i) with an established bovine derived bone mineral for regeneration of intra-bony peri-implantitis defects.
To evaluate and compare PSA-glycosylation patterns in semen of prostate cancer patients and healthy controls.To correlate PSA-glycosylation patterns in semen with pathological tumour stage and Gleason grade in prostate cancer patients.
In the current project we will investigate multiple risk factors and their interaction in a single study design, aiming to identify different profiles associated with social withdrawal behaviour in an Ultrahigh Risk and First Episode Psychosis…
Primary Objective:To assess whether the clinical efficacy of RPC1063 is superior to interferon (IFN) *-1a (Avonex®) inreducing the rate of clinical relapses in patients with RMS.Secondary Objectives:- To assess the effect of RPC1063 on the…
1. The objective of this study is to aquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading. We want to investigate if patients with diabetes type 2 will develop…
To extend and strengthen the initial pilot observations on PKD red blood cells, and thereby further establish the activity of AG-348 treatment for PKD, UMC Utrecht and Agios Pharmaceuticals will collaborate in this pre-clinical study. In particular…
The current study is set up to validate the working mechanism of the current design of the FemFlow.
Ticagrelor, at steady state (i.e. after 30 days), will be associated to an improved endothelial function as compared to clopidogrel or prasugrel.
The study will be performed in 2 parts, Parts A and B. The purpose of Part A of the study is to investigate the safety of VX 150 and to what extent a single dose of VX 150 is tolerated. It will also be investigated how quickly and to what extent a…
To investigate the occurrence and burden of morning symptoms in outpatients diagnosed with COPD gold II-IV.
• To evaluate the tolerability and safety of ascending single oral doses of ACT-541468 in healthy male subjects.• To investigate the single oral dose pharmacokinetic (PK) and PD of ACT-541468 in healthy male subjects.• To investigate dose…
Primary Objective: to investigate whether the variation of the number of lumbar vertebrae in humans is coded by the same genes which are responsible for this as well as in other mammals.