2170 results
We aim to recognise potential genetic modifiers for mutations in PMS2. This will be approached through comparing a selection of CRC-related genes in the exome of members of a PMS2 family who differ in age of onset and severity of disease.
Primary objective:Plasma levels of clonidine, in order to describe pharmacokinetic and pharmacodynamic properties of intravenous clonidine in critically ill ventilated ICU patients.Secondary objectives are: * to evaluate the effect of a 3-hr loading…
This study is not intended to improve your health, but is necessary for the further development of RO7034067 .The study will be performed in 3 parts, Parts 1, 2 and 3. This document only refers to Part 1/2/3 of the study . Part 1:A single dose will…
Main objective of this phase 2 trial is to evaluate efficacy of nivolumab in symptomatic brain metastases of metastatic melanoma patients. In addition, the efficacy will be compared between patients with previously locally treated (e.g. surgery,…
Primary Objective: The primary objective is to study the potential role of F. nucleatum in the development of colorectal cancer by isolating F. nucleatum strains from large adenoma biopsies, healthy colorectal tissue and matching stool and saliva…
To evaluate the efficacy of VX-661 in combination with ivacaftor through 24 weeks of treatment in subjects with cystic fibrosis (CF) who are homozygous for the F508del mutation on the CF transmembrane conductance regulator (CFTR) gene.
To assess the prevalence of QTc-prolongation in patients who are prescribed two or more QTc-prolongating drugs as part of usual care, and to assess potential risk factors for that QTc-prolongation.
It is hypothesized that the type of radiographs and patient positioning is influential on the measured relative and absolute shortening of the MSCF. The goal of this study is to investigate to what extent the type radiograph used and patient…
The current pilot study will explore 1) whether the effect of blended parent training is noninferior to the effect of face to face parent training, 2) whether therapist time can be reduced by offering the intervention partially online, 3) whether…
The primary objective is to determine new biological properties of uterine fibroid tissue using advanced MRI image sequences and to correlate these properties with the currently used simple Funaki classification and with clinical symptoms.The…
In this laboratory study, we will examine the properties of leukemic stem cells and the immuno-modulatory effects of bosutinib and imatinib in newly diagnosed chronic phase CML patients. Further, we aim to study whether they have an impact on the…
The main objective is to evaluate the cytokine response to tape stripping in vivo, dynamically and non-invasively by means of patches..The secondary objectives are (i) to correlate the cytokine response with transepidermal water loss (TEWL), a well-…
The objective of this study is to evaluate the clinical validation of a sensitive molecular assay to detect the presence of wild-type (so-called *full-length*) and alternatively spliced variants (ARV) of the AR in enriched CTC of patients with CRPC…
To identify and define characteristics of ILD on the pCLE and pOCT image of airway wall mucosa and the alveolar compartment and compare this to HRCT imaging and pathology.
The primary objective of this study is• To assess the efficacy of vilaprisan in subjects with uterine fibroids compared to placebo.The secondary objectives of this study are• To assess the efficacy of vilaprisan in subjects with uterine fibroids…
(1) To phenotype fibromyalgia patients in terms of endogenous modulation of pain, central sensitization/facilitation, the presence of a neuropathic pain component and small fiber neuropathy;(2) To assess the effect of a three-month treatment with…
Primary objectives:(1) To determine the safety and tolerability of pembrolizumab. (2) To evaluate the Overall Response Rate (ORR) of pembrolizumab by independent central review according to the International Working Group (IWG) response criteria (…
1.To create insight in current disease burden by creating a descriptive cohort of patients, diagnosed with rare congenital hemolytic anemia. Points of interest are:- Prevalence and incidence of disease- Quality of life- Prevalence and incidence of…
Primary objective is to study the number of patients gaining at least 50% pain reduction within 8 weeks following PRF as compared to following a neurectomy. Pain intensity will be measured using numeric pain rating score (NPRS, 0-10) and Verbal…
to investigate pathogenic mechanisms in synovial tissue driving inflammatory rheumatic diseases in relationship to phenotype, disease duration and stage and in relation to systemic immunity, to identify new diagnostic and therapeutic targets.