2076 results
In this study, behavioral tests will be performed during the fMRI scan to investigate the brain*s response to these tests. Behavioral tests will also be performed outside the scanner. The results of the study will be used for optimizing the fMRI…
This mapping study will contribute to our understanding of the pathogenesis of ACNES and the complex anatomical distribution of sensory input of the trunk. It will also pave the way for a better diagnostic work-up, allowing for better surgical…
Assessment of value of DECT scan in diagnosing acute arthritis, caused by gout
Primary Objective• To collect data regarding changes in oxalate, glycolate, and other metabolites over time in subjects with primary hyperoxaluria type 1 (PH1) who may be considered for clinical trials of DCR PH1Secondary Objectives• To collect data…
To study IVCM backscatter measurements as a usefull measurement to decide between surgical indications.
To evaluate the safety and performance of MANTA in achieving hemostasis in femoral arterial access sites in patients undergoing percutaneous transcatheter interventional procedures using a 10-18F procedure sheath for purposes of obtaining a CE Mark…
Phase 2: To evaluate progression-free survival (PFS) as the primary efficacy measure of MLN1117 plus docetaxel versus docetaxel alone in patients with advanced NSCLC
The aim of this monocenter observational pilot study is to determine the incidence and severity of gastric emptying disorders in patients with a hiatal hernia and to observe the effects of hiatal hernia repair and fundoplication on the gastric…
Examine in vivo muscle energy metabolism in patients with burns, during rest, (prolonged) exercise and recovery.
Primary objective• To explore the pharmacodynamic effects on a target lesion of topically applied omiganan in AD patientsSecondary Objectives• To assess safety and tolerability in AD patients• To evaluate the efficacy of omiganan compared to placebo…
Primary ObjectiveTo determine the prevalence of respiratory viral colonization/infection in pre-term born neonates during hospitalisation.Secondary Objectives1. To study the relation of viral respiratory colonization with respiratory support2. To…
To investigate the potential value of magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) on a 3 Tesla MRI system to visualize the spinal cord in SMA patients and to investigate motor connectivity in vivo in patients with SMA.
Primary ObjectiveTo evaluate and compare the pharmacokinetic (PK) parameters (AUC0-t, AUC0-inf, Cmax, C24hr, Tmax, and apparent t*) of MK-3682 and its circulating metabolites MK-5172, and MK-8742 following administration of three test premarket…
The main goal of this study is to answer the following questions: What is the relative contribution of the photoreceptors for the NIF effects of pupil constriction and alertness? What are the frequencies of light which minimise the adaptation of the…
To study the effect of the use of the LV 1 System with the Sentinel System, during TAVR, with respect to procedure-related cerebral embolic burden in patients assessed by DW-MRI. To limit data variability and avoid confounding effects of different…
The primary objectives of this study are to assess whether 80 mg ixekizumab every 2 weeks (Q2W) is:• noninferior to ustekinumab at Week 12 in the treatment of patients with moderate-to-severe plaque psoriasis as measured by proportion of patients…
to investigate the additional value of the use of inhaler specific instruction cards in inhaler education in patients with asthma or COPD.
Objective: Bread aroma may increase consumer*s motivation to buy bread. Motivation for products is hard to measure reliably in real life settings like a supermarket, but can be studied via brain imaging. In this project, brain imaging is used to…
The main study aim is the in vivo and ex vivo investigation of the expression and distribution of the GLP-1R in the pancreas of children (< 16 years) with proven endogenous congenital hyperinsulinism who qualify for surgery based on response…
Our goal is to build a faster SPES algorithm for execution and analysis which produces the same information as the current, classic SPES protocol. This faster protocol is obtained by predicting optimal stimulus parameters and settings in a computer…