2170 results
To implement the 13C breath test for measuring gastric emptying rate in healthy volunteers at NIZO food research. To obtain insight in variation of measures of gastric emptying for specific model foods.
The aim of this study is to determine whether the addition of adenosine to standard intermittent warm blood cardioplegia reduces the 6-hours post-operative cTnT in patients scheduled for minimally invasive, port access operations (mitral valve…
To evaluate the safety and efficacy of a single oral dose of vanoxerine for the conversion of subjects with recent atrial fibrillation (AF) or atrial flutter (AFL) to normal sinus rhythm.
Is it possible to increase the spatial match between PET and CT imaging with the use of a respiratory instructed breath hold CT?
The primary objective is to investigate the effect of conditioning with oxytocin on endogenous oxytocin release. Secondary, we will investigate the effect of oxytocin conditioning on cortisol and on brain activity, both in resting state and in…
The primary objective of this study is to investigate the safety and feasibility of implanting a WATCHMAN Device in a hybrid setup for AF ablation.
The purpose of the study is to investigate how quickly and to what extent radiprodil is absorbed and eliminated from the body (this is called pharmacokinetics). It will also be investigated to what extent radiprodil is tolerated. In addition, 2 new…
Pilot study:Primary objective: feasibilitySecondary objectives: response rate, time to progression, overall survival and quality of life.Phase II study:Primary objective: efficacy.Secondary objectives: toxicity, especially grade 3 and 4 toxicities,…
Primary Objective: • Investigate if CT is a reliable modality to detect blood flow distal to the LAAO device validated by TEE.Secondary Objective(s): • Evaluate the reproducibility of position and blood flow measurements: inter and intra observer…
To investigate whether bacterial translocation to pancreatic beta cells is increased in type 2 diabetes mellitus patients. Moreover, we will study which bacterial strains are involved translocation. Finally, we will obtain and culture beta cells to…
This study aims to chart which thermal challenges modern day humans are exposed to and compare this to their thermoneutral zone. Therefore we hypothesize that modern day humans (both males and females) are predominantly within their thermoneutral…
We aim to obtain more insight in the pathogenesis of DS. This replication study will focus on molecular determinants suchs as methylation and gene transcription. In addition, we will collect phenotypic information and link this with information…
The objective of the MORE studies is to select and validate a biomarker profile predictive for the response to weekly paclitaxel and carboplatin chemotherapy concomitant with radiotherapy in patients with esophageal cancer.In the MORE-1 pilot study…
The main objective of this study is to gain insight into the possible long-term effects, up to 5 years of age, on growth and body composition development of an infant formula containing a new fat blend given in the first 4 months of life
The purpose of this study is to see if JNJ-42847922 is useful for treating patients with insomnia without any other psychiatric disease. The safety of JNJ-42847922 will also be studied.
The two objectives of the study are:(1) to determine te concentrations of nicotine, propylene glycol, glycerol, formaldehyde, acetaldehyde, acrolein, diacetyl, tobacco-specific nitrosamines and metals (V, Cr, Mn, Ni, Cu, Zn, As, Cd, Sn and Pb) in…
In this study we will use the BalRoom and the Radboud Falls Simulator to investigate the hypothesis that reduced balance capacity in elderly is related to deficient sensory and motor systems involved in balance control.
To investigate postoperative nausea and vomting in patients with or without a gauze throat after an operation of the mouth
To determine the safety and efficacy of coversin in the treatment of patients with PNH resistant to eculizumab.
Primary objectiveThe primary objective of this trial is to determine the visibility and positional accuracy of laser marks applied by the NvisionVLE Imaging System.