2170 results
Main objective of this phase 2 trial is to evaluate efficacy of nivolumab in symptomatic brain metastases of metastatic melanoma patients. In addition, the efficacy will be compared between patients with previously locally treated (e.g. surgery,…
Primary Objective: The primary objective is to study the potential role of F. nucleatum in the development of colorectal cancer by isolating F. nucleatum strains from large adenoma biopsies, healthy colorectal tissue and matching stool and saliva…
Primary objective:To determine the safety and tolerability of multiple, once-daily oral doses of CNP520 over 13 weeks in healthy elderly subjectsSafety: ECG, vital signs and laboratory data; assessment of cognitive function; dermatological…
To evaluate the efficacy of VX-661 in combination with ivacaftor through 24 weeks of treatment in subjects with cystic fibrosis (CF) who are homozygous for the F508del mutation on the CF transmembrane conductance regulator (CFTR) gene.
To assess the prevalence of QTc-prolongation in patients who are prescribed two or more QTc-prolongating drugs as part of usual care, and to assess potential risk factors for that QTc-prolongation.
It is hypothesized that the type of radiographs and patient positioning is influential on the measured relative and absolute shortening of the MSCF. The goal of this study is to investigate to what extent the type radiograph used and patient…
The current pilot study will explore 1) whether the effect of blended parent training is noninferior to the effect of face to face parent training, 2) whether therapist time can be reduced by offering the intervention partially online, 3) whether…
The primary objective is to determine new biological properties of uterine fibroid tissue using advanced MRI image sequences and to correlate these properties with the currently used simple Funaki classification and with clinical symptoms.The…
For the primary objective: To quantify the effect of natural extract added to a wheat product on the time needed to absorb 50% of the apparent total of available exogenous carbohydrate (RaE * Time).
In this laboratory study, we will examine the properties of leukemic stem cells and the immuno-modulatory effects of bosutinib and imatinib in newly diagnosed chronic phase CML patients. Further, we aim to study whether they have an impact on the…
The main objective is to evaluate the cytokine response to tape stripping in vivo, dynamically and non-invasively by means of patches..The secondary objectives are (i) to correlate the cytokine response with transepidermal water loss (TEWL), a well-…
The objective of this study is to evaluate the clinical validation of a sensitive molecular assay to detect the presence of wild-type (so-called *full-length*) and alternatively spliced variants (ARV) of the AR in enriched CTC of patients with CRPC…
To identify and define characteristics of ILD on the pCLE and pOCT image of airway wall mucosa and the alveolar compartment and compare this to HRCT imaging and pathology.
The primary objective of this study is• To assess the efficacy of vilaprisan in subjects with uterine fibroids compared to placebo.The secondary objectives of this study are• To assess the efficacy of vilaprisan in subjects with uterine fibroids…
(1) To phenotype fibromyalgia patients in terms of endogenous modulation of pain, central sensitization/facilitation, the presence of a neuropathic pain component and small fiber neuropathy;(2) To assess the effect of a three-month treatment with…
Primary objectives:(1) To determine the safety and tolerability of pembrolizumab. (2) To evaluate the Overall Response Rate (ORR) of pembrolizumab by independent central review according to the International Working Group (IWG) response criteria (…
1.To create insight in current disease burden by creating a descriptive cohort of patients, diagnosed with rare congenital hemolytic anemia. Points of interest are:- Prevalence and incidence of disease- Quality of life- Prevalence and incidence of…
Primary objective is to study the number of patients gaining at least 50% pain reduction within 8 weeks following PRF as compared to following a neurectomy. Pain intensity will be measured using numeric pain rating score (NPRS, 0-10) and Verbal…
to investigate pathogenic mechanisms in synovial tissue driving inflammatory rheumatic diseases in relationship to phenotype, disease duration and stage and in relation to systemic immunity, to identify new diagnostic and therapeutic targets.
The aim of this study is to investigate the effects of early start versus delayed start of oral intake on postoperative recovery and pulmonary complications following esophagectomy. This is a non-inferiority trial.