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A prospective multicenter cohort study to evaluate the benefit of the geriatric fracture center (GFC) concept * Evaluation of a geriatric co-management program

To investigate the effect of a GFC regarding major adverse events (AE) with a relationship to the treatment / residential status / immobilization (as defined under "Primary outcome measures") from surgery to a 36 month follow-up.

An open-label randomized two-arm Phase I dose-escalation study to characterize the safety, tolerability, pharmacokinetics, and maximum tolerated dose of oral BAY 1217389 in combination with weekly intravenous paclitaxel given in an intermittent dosing schedule in subjects with advanced malignancies

The primary objectives of this study are to:* Determine the safety, tolerability, maximum tolerated dose (MTD), and recommended Phase 2 dose (RP2D) of oral BAY 1217389 given in combination with intravenous (IV) paclitaxel using an intermittent…

Laparoscopic versus open distal pancreatectomy for symptomatic benign, premalignant and malignant disease

To determine whether time to functional recovery is shorter after LDP than after ODP for symptomatic benign, premalignant and malignant disease of the distal pancreas in an enhanced recovery setting.

AN OPEN-LABEL, PHASE Ia/Ib/IIa STUDY OF GDC 0810 SINGLE AGENT OR IN COMBINATION WITH PALBOCICLIB AND/OR AN LHRH AGONIST IN WOMEN WITH LOCALLY ADVANCED OR METASTATIC ESTROGEN RECEPTOR POSITIVE BREAST CANCER

Primary ObjectivePhase Ia* To determine the maximum tolerated dose (MTD) and/or recommended Phase II dose (RP2D)and assess the safety of single agent GDC-0810 in postmenopausal women with locally advanced or metastatic estrogen-receptor-positive (ER…

An open label extension study to investigate the safety of cannabidiol (GWP42003-P; CBD) in children and adults with inadequately controlled Dravet or Lennox-Gastaut Syndromes

To evaluate the long term safety and tolerability of GWP42003-P, as adjunctive treatment, in children and adults with inadequately controlled DS or LGS.All Patients:To evaluate the effect of GWP42003-P, as adjunctive treatment, on:* Quality of life…

Internal Plate Fixation versus Plaster in Complete Articular Distal Radius Fractures

To determine the difference in functional outcome between open reduction and internal platefixation and closed reduction and plaster immobilisation in patients with displaced complete articular distal radius fractures.

In Vivo Imaging of Neuroinflammation in Simvastatin-Treated Schizophrenic Patients

The primary objective of this study is to determine if the binding of [11C]PK11195, as a measure of neuroinflammation, in schizophrenic patients is decreased after simvastatin treatment.

Health risks of anabolic steroid use by amateur athletes.

Niet van toepassing.

Advanced glycation end products in patients with peripheral artery disease or abdominal aortic aneurysms

The primary objective is to compare the amount, type and localisation of AGEs of the arterial wall of PAD, AAA and PAD+AAA in patients with and without diabetes mellitus.The secondary objectives are to explore the association between AGEs content of…

A Phase 3, Multicenter, Open-label, Randomized Study of SGI-110 versus Treatment Choice (TC) in
Adults with Previously Untreated Acute Myeloid Leukemia (AML) Who Are Not Considered Candidates for Intensive Remission Induction Chemotherapy

To assess and compare efficacy (complete response [CR] rate and overall survival [OS]) between SGI-110 and TC in adults with previously untreated AML who are not considered candidates for intensive remission induction chemotherapy.

Simband Data Collection

Objective: Gather data on the use of Simband, positioned at the wrist, to estimate BP based on data from Simband*s ECG and PPG sensors, compare these results to the existing cuff-based BP measurements during haemodialysis treatment and apply the…

A PHASE III, OPEN-LABEL, MULTICENTER, RANDOMIZED STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF ATEZOLIZUMAB (ANTI*PD-L1 ANTIBODY) COMPARED WITH CHEMOTHERAPY IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC UROTHELIAL BLADDER CANCER AFTER FAILURE WITH PLATINUM-CONTAINING CHEMOTHERAPY

This is a phase III, open-label, multicenter, randomized study to investigate the efficacy and safety of atezolizumab (anti PDL1 antibody) compared with chemotherapy in patients with locally advanced or metastatic urothelial bladder cancer after…

Antivirals for influenza Like Illness? An rCt of Clinical and Cost effectiveness in primary CarE (ALICE)

ALICE is a randomised controlled trial in Primary Care that aims to determine whether adding antiviral treatment to best usual primary care is effective in reducing time to return to usual daily activity and so the clinical and cost effectiveness of…

The Efficacy and Safety of Bimatoprost SR in Patients With Open-angle Glaucoma or Ocular Hypertension

To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 2 dose strengths of Bimatoprost SR in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT) after initial and repeated administrations

THE TEMSTEM TRIAL: Reducing distress and dysfunction caused by auditory verbal hallucinations via a smartphone application.

The primary objective is to test the effects of temstem on distress, disturbance to life and social functioning. Second, we aim to investigate the effect of temstem on frequency and severity of AVH, to determine working mechanisms, to identify…

The Clinical Efficacy And Subclinical Effects on arterial STIFFNESS of bosentan therapy added to usual care in patients with systemic sclerosis with digital ulcers.

To investigate whether bosentan added to usual care improves arterial stiffness after 3 months as measured as the pulse wave velocity (PWV) of the medium and large arteries corrected for blood pressure changes in patients with SSc with digital…

The efficacy of core-stability training on drop-out and injury risk in basic military training of the Dutch Marine Corps.

Our primary objective is to assess the preventive effects of core stability training in reduction of the incidence density for injury and dropout rate in the Basic Dutch Marine Corps Training 15/2 , 16/1 and 16/2.We want to establish the preventive…

Optimizing DMARD therapy for primary Sjogren's Syndrome - Leflunomide and Hydroxychloroquine combination therapy for patients with primary Sjogren's Syndrome

In a clinical trial it will be investigated to what extent combination therapy with LEF and HCQ will 1) inhibit disease activity, in particular improvement of ESSDAI and dryness and 2) inhibit activity of (autoreactive) B-cells, T-cells and pDCs. In…

A multicenter, multinational, randomized, controlled, open label study, performed in children with thermal burns, to evaluate the efficacy and safety of NexoBrid as compared to standard of care (SOC) treatment

To evaluate the safety and clinical benefit of NexoBrid in hospitalized children (0-18 years) with deep partial and/or full thickness thermal burns of 1-30% TBSA and to compare NexoBrid to standard of care (SOC).

Long term follow-up of perichondrial transplants for the repair of cartilage defects in the human knee by 7 tesla MRI

The aim of this study is to evaluate the quality of the cartilage of repaired defects 20-25 years after perichondrium transplantation (PT) or autologous chondrocyte translantation (ACT). Secondary objectives are to review the functionality and pain…