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Multicenter, randomized, double-blind, parallel-group extension to study AC 058B201 to investigate the long-term safety, tolerability, and efficacy of 10, 20, and 40 mg/day ponesimod, an oral S1P1 receptor agonist, in patients with relapsing-remitting multiple sclerosis

* To investigate the long-term safety and tolerability of ponesimod * To investigate the long-term efficacy of ponesimod* To explore the dose response relationship of 10, 20 and 40 mg ponesimod on lymphocyte count, MRI endpoints and annualized…

Open-label, multicenter study of the 18F labeled PET/CT (positron emission tomography / computed tomography) tracer BAY 86-9596 following a single intravenous administration of 200 or 300 MBq (corresponding to <= 18 µg mass dose), for evaluation of radiation dosimetry, plasma pharmacokinetics, safety and tolerability in healthy volunteers (200 MBq) as well as investigation of safety, tolerability and diagnostic performance in patients (300 MBq) with non small cell long cancer, breast cancer, hea

Primary objective:Explorative investigation of the tumor detection rate with BAY 86-9596 in comparison to that of 18F-fluorodeoxyglucose (FDG)Secondary objectives:- Determination of radiation dosimetry and pharmacokinetics of BAY 86-9596 in healthy…

Functional analysis of molecular mechanisms underlying parasympathetic regulation of human adipose

To characterize the molecular mechanisms underlying parasympathetic regulation of adipose tissue.

BIOTRONIKS-Safety and Clinical Performance of the First Drug-Eluting Generation Absorbable Metal Stent In Patients with de Novo Lesions in Native Coronary Arteries (BIOSOLVE-I study)

To evaluate safety and clinical performance of the investigation product (drug-eluting absorbable metal stent system)