2673 results
The purpose of this study is to evaluate if the addition of daratumumab to Bortezomib, Thalidomide and Dexamethasone will increase the stringent complete response rate after consolidation therapy and increase the progression free survival after…
The aim of the NEtherlands Chlamydia Cohort STudy (NECCST) is to assess the risk of developing complications and the time to pregnancy in women with and without a known previous Ct infection. Furthermore, this study aims at determining host genetic…
This study has been transitioned to CTIS with ID 2024-513521-23-00 check the CTIS register for the current data. All efficacy and safety objectives will compare enzalutamide plus leuprolide and enzalutamide monotherapyversus placebo plus leuprolide.
Primary objectives:-Evaluate the safety and tolerability of AMG 330 in adult subjects with relapsed/refractory acute myeloid leukemia (R/R A ML), MRD+ AML and MDS-Estimate the maximum tolerated dose (MTD) and/or a biologically active dose (eg,…
This study aims to evaluate the impact of UAE on Quality of life (QOL) in comparison to hysterectomy in adenomyosis patients. A cost-effectiveness study will be part of the trial as well as a cohort hysterectomy group to clearify imaging and…
1) The validation of the SKPI used in children with a developmental age of 3 to 8 years old.Hypothesis:- By using the SKPI the examiner will be able to distinguish children who are victims of CSA from children who are not.2) The demonstration of the…
Research question(s). There are two specific questions to be addressed:1) Is percutaneous transforaminal endoscopic discectomy (PTED) no worse in effectiveness than conventional unilateral open microdiscectomy for patients with symptomatic…
This study has been transitioned to CTIS with ID 2023-509136-25-00 check the CTIS register for the current data. To prospectively assess whether post-operative adjuvant therapy with pembrolizumab improves recurrence-free survival (RFS) as compared…
Primary Objective Our primary aim is to compare cognitive decline at 3 months, defined as a significant decline (5 point decrease from baseline based on the reliable change index with correction for practice effects) in HVLT-R Total Recall score (…
In this study we want to investigate the efficacy and safety of an implant system with a surface coating (Biocomp) for episthetic reconstruction after ablative surgery in the nasal, orbital and auricular region
To determine the maximum tolerated dose (MTD) of ModraDoc006/r (as ModraDoc006 10 mg tablets in combination with one tablet of 100 mg ritonavir) that can safely be administered in a bi-daily weekly schedule in combination with high-dose intensity…
The primary objective of the present study is to assess the involvement of the duodenal TRPV-1 neuropeptide pathway in symptom perception in FD patients compared to healthy controls. The present study has several secondary objectives with regard to…
Primary objective is to analyse vasoreactivity of the vascular system of patients with and without heart failure, in and ex vivo. Secondary objectives are to identify signal transduction pathways associated with the altered vasoreactivity in this…