142 results
To draw definite conclusions about the effectiveness of omega-3 PUFA supplementation in anorexia nervosa patients a double-blinded, placebo-controlled randomized controlled trial (RCT) with a substantial sample size should be conducted. Prior to…
To investigate whether non-invasive ear magnetic acupuncture will help reduce pain and stress for preterm infants in the Neonatal Intensive Care Unit (NICU) during their routine eye examination for Retinopathy of Prematurity (ROP).
Primary Objective: To assess the agreement between the heart rate assessed with a dedicated cap with integrated PPG-leads and standard ECG monitoring using regular neonatal thoracic electrodes as reference technique.Secondary objectives:Does…
To prove that sustained clinical remission can be maintained at week 14 with a new dietary strategy that involves only 2 weeks of EEN with Modulen and 22 weeks of an exclusion diet involving selected table foods. We hypothesize that use of EEN for…
To evaluate the safety of BIVV001 in previously treated pediatric subjects with hemophilia A.
The aim is to study the effectivity of a brief, intensive, outpatient group treatment (ERP) for youths with chronic tic disorders/Tourette Syndrome (TS), to improve treatment outcome, daily functioning/quality of life and treatment satisfaction. If…
The aim of this study is to compare the effect of early treatment on healing and quality of life with the usual expectant policy in children with mollusca contagiosa.
The quality and quantity of the innate immune response to bacteria should be tightly regulated leading to resolution of infection while minimizing damage to host tissue. We hypothesize that this regulation depends on gestational age at delivery and…
Primary objective is to investigate the effectiveness of the KLIK Pijnmonitor in reducing clinically significant pain in children at home by comparing the proportion of clinically significant pain between the intervention group and the control group…
Primary Objective:To demonstrate the efficacy of repeated daily doses of 120 µg/kg/day odevixibat in relieving pruritus in patients with ALGS.Secondary Objectives:To assess the impact of odevixibat on serum bile acid levels in patients with ALGS.To…
Primary objective:1. To identify the components in human milk (e.g. nutrients, oligosaccharides, fatty acids and (pathogen specific) immunoglobulins) that have a protective effect against respiratory tract infections during the first year of life.…
1) To study the effects of antibody removal by immunoadsorption on the immune phenotype over time in patients with B-cell related autoimmune diseases such as MG, AAV, anti-GBM disease, cryoglobulinemic vasculitis and other refractory antibody-…
The primary objective is to determine the efficacy of methylphenidate on ADHD symptoms in Smith Magenis syndrome.The secondary objectives include the efficacy of methylphenidate on emotion dysregulation and specific goals that are important to the…
This study will evaluate the safety, tolerability, and pharmacokinetics of idasanutlin as a single agent and the safety, tolerability, pharmacokinetics, and preliminary efficacy of idasanutlin in combination with either chemotherapy or venetoclax in…
The main objective of this longitudinal study is to gain insight into the neurodevelopmental trajectories following neonatal critical illness, from the perinatal period to school-age compared to healthy controls. This insight may lead to the…
This study has been transitioned to CTIS with ID 2024-516123-13-00 check the CTIS register for the current data. Part I:Primary Objective: Evaluate the effects of tiratricol on neurodevelopment in young MCT8 deficiency patients, as measured by the…
This study has been transitioned to CTIS with ID 2023-504821-38-00 check the CTIS register for the current data. Goal of this study is to determine the optimal balance between maintaining high rates of OS in this group and avoiding the long-term…
To determine the (cost)-effectiveness of home-based hypnotherapy by self-exercises added to usual care (UC) of general practitioners (GPs) compared with UC of GPs alone in children with FAP or IBS.
To quantify the role of different abnormal loading conditions on atrial and ventricular electropathology in paediatric patients with CHD.