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Multicenter trial of elective revascularization in patients with diabetes mellitus and mild anginal complaints.

To determine whether a strategy of invasive treatment (relative to continued medical treatment) of patients with type 2 diabetes mellitus, mild symptoms of stable angina pectoris, and documented myocardial ischemia lead to a decrease in cardiac…

Colonic stenting or surgery in left sided colonic obstruction for disseminated incurable colorectal cancer: a multicenter randomised trial.

Patient with incurable disseminated left-sided colonic cancer are better palliated by colonic stenting than surgery measured by hospital free survival in "good health"(WHO-score 0 or 1) Colonic stenting is cost effective in patients with…

Onderzoek naar de effectiviteit van het transmuraal stoppen-met-roken project STOPPERS.

1. Welke rokers hebben baat bij welke transmurale “stoppen-met- roken- interventiestrategie”?; 2. Wat zijn de effecten van de verschillende “stoppen-met- roken- interventiestrategieën”?

Parametric cochlear implant map adjustment by implant recipients.

Speech understanding with a speech processor fitted using the parametric fitting procedure and the recipient's own fine-tuning is as good as with a conventional fitting. The parametric fitting is more patient friendly and less time-consuming.

Effects of guiding informal caregivers of terminal cancer patients who stay at home, by district nurses who are specialized in palliative care / oncology.

Informal caregivers in the experimental group are expected to be more satisfied with the care provided to them and the patient they take care of, to experience a less heavy burden, and to have a better health compared to the informal caregivers who…

Dyspepsia - Buspiron.

HAART followed by maintenance with monotherapy-Kaletra (MAIMOKA).

N/A

An Open Label Trial of Anti-TNFa Chimeric Monoclonal Antibody (Infliximab, Remicade®) in the Treatment of Endogenous Uveitis or Vasculitis unresponsive to Standard Therapy.

Multi-centre open label clinical trial.

The effect of intrathecal methylprednisolone on features of central sensitization in patients with Chronic Complex Regional Pain Syndrome Type 1.

Intrathecal methylprednisolone reduce the features of central sensitization in patients with complex regional pain syndrome type 1 having symptoms longer than 6 months and shorter than 6 years.

Melatonin for children with idiopathic chronic sleep onset insomnia, with or without attention deficit hyperkinesia disorder - A dosefinding trial.
A randomised placebo-controlled double-blind parallel group trial.

Chronic sleep disorders are associated with dysfunctioning during the day. Circadian rhythm disorders are a frequently occurring cause of chronic sleep disorders. The time at which the endogenous melatonin production starts to rise plays a key-role…

The effectiveness of the self-help course 'In de put, uit de put' through the Internet.

N/A

Therapeutic Drug Monitoring in HIV-Infected Children Starting a New Anti-Retroviral Regime.

The effect of the TDM strategies on the viral load in terms of change from baseline (start or switch of therapy) to 96 weeks.

Open randomized study of previously untreated metastatic prostate cancer patients comparing intermittent to continuous treatment with cyproterone acetate. Evaluation of step-up therapy adding an LHRH agonist upon progression is included.

Intermittent androgen deprivation using CPA oral monotherapy improves the overall quality of life while achieving similar control of tumour growth to that attained by continuous CPA treatment.

Growth and development of children born after IVF.

Conditions during an IVF procedure might interfere with fetal growth and development and thereby permanently influencing the programming of organs and their function.

An international randomized trial in Locally Advanced Breast Cancer comparing 6 courses of neo-adjuvant doxorubicin and cyclophosphamide plus GM-CSF or G-CSF with a split-course administration of 3 neo-adjuvant and 3 adjuvant cycles including either GM-CSF or G-CSF.

To detect any effect on disease-free survival from treatment with 3 neo-adjuvant and 3 adjuvant chemotherapy cycles (standard treatment) versus 6 neo-adjuvant chemotherapy cycles To study the effect of GM-CSF versus G-CSF on potential effect on…

Schizophrenia Termination Of Pharmacotherapy-STOP-trial.

H0: continuation or cessation of antipsychotic therapy in psychosis free stable first episode patients with a schizophrenic disordermakes no difference with regard to relapse rates or side-effects.

Dyspepsia - Amitriptyline.

N/A

Observational cohort of patients treated with stereotactic radiotherapy for Oligo LYMPh nOde and other soft tissue metastasiS; the OLYMPOS cohort

The main clinical challenge remains to identify patients who may benefit from aggressive local treatment (stereotactic radiotherapy, SBRT) of soft tissue oligometastases: for which patients can systemic treatment be postponed? Patients who are…

The effect of smoking status on the treatment of non-small cell lung cancer with immunotherapy

Mortality will be lower in patients who do not smoke during treatment of non-small cell lung carcinoma with PD-L1-inhibitors compared to patients who smoke during their treatment with PD-L1-inhibitors.

Delirium treatment at the surgical ward (DELTa S)
Treatment of delirium: rivastigmine or haloperidol as primary treatment for delirium in elderly patients with a fractured hip.
A randomized placebo-controlled study.

Rivastigmine is as effective in the treatment of delirium as Haloperidol.