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Mood Disorders in Elderly and ECT (Electroconvulsive therapy): Electroconvulsive therapy can induce brain derived neurotrophic factor in serum and increase cortisol levels to enhance neurorestorement of hippocampal volume and function.

To predict and evaluate the effectively and safety of ECT in depressed elderly.1. the relation between clinical parameters and the safety and effectively of ECT in elderly with a severe depressive disorder2. the relation between structural brain…

A single arm, open-label, multicenter study evaluating the long-term safety and tolerability of 0.5 mg fingolimod (FTY720) administered orally once daily in patients with relapsing forms of multiple sclerosis (CFTY720D2399- LONGTERMS)

Primary: Safety and tolerability of fingolimod 0,5 mg.Secundairy: Long-term efficacy.Exploratory: Patient-Reported Outcomes Indices for Multiple Sclerosis (PRIMuS) and Short Form Health Survey*12 (SF-12), Treatment Satisfaction Questionnaire for…

Breast conserving therapy using Accelerated Partial Breast Irradiation (APBI) in elderly patients: a feasibility study

Confirm favorable treatment results of international studies.Relate (loco regional) tumor control, side effects and (inter current) death to geriatric questionnaires/condition, co-morbidity and usage of medication.

Immunological (mis)communication in Langerhans Cell Histiocytosis

The main objective of our study is to gain more insight into the molecular processes preceding the onset and course of LCH. Moreover, we try to understand the role of the immune system, if any, in the clearance of histiocytes which are typically…

Occipital nerve stimulation in medically intractable, chronic cluster headache

Primary: To demonstrate that high (100%) stimulation of ONS therapy reduces the mean attack frequency (MAF) in MICCH by at least 35% compared to low (30%) stimulation of ONS.Secondary: To evaluate • the rate of responders (>= 50% reduction in…

A Prospective Clinical Series followed by A Multicenter Double-blind Randomised Placebo-Controlled Clinical Trial

Primary Objective: To prove the hypothesis that Intradiscal Methylene blue is capable of longer pain reduction and better global perceived effect in patients suffering from chronic axial low back pain from discogenic origin then a placebo treatment…

Carfilzomib in combination with Thalidomide and Dexamethasone for remission induction and consolidation of Multiple Myeloma at first presentation

To assess the feasibility and efficacy of Carfilzomib in combination with Thalidomide and Dexamethasone in a phase II trial.

A prospective, multicenter, clinical outcome study of the NANOS neck preserving stem in patients with degenerative hip joint disease.

To prove that the NANOS prosthesis is a good prosthesis to be used in total hip replacement surgery, with low revision rate (< 10%) after 10 years. This percentage is known in the Swedish registry.Second objective is to prove that clinical…

T-cell turnover during HIV infection; production and life span of T-cells in HIV infected
individuals during cART

With this research we aim at gaining more insight into the reason for the fact that some individuals reconstitute well during cART whereas other do not. Also, we would like to investigate what mechanism is responsible for reconstituting the CD4 T-…

A multicenter randomized phase III trial of neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy in resectable gastric cancer (CRITICS-study: ChemoRadiotherapy after Induction chemoTherapy In Cancer of the Stomach).

This study investigates whether chemoradiotherapy (45 Gy in 5 weeks with daily cisplatin and capecitabine) after preoperative chemotherapy (3x ECC (epirubicin, cisplatin, capecitabine)) and adequate (D1+) surgery leads to improved survival in…

1. Comorbidity and Aging with HIV. An observational study.
2. AGEhIV substudy nr 1

1A) To implement a screening-protocol for HIV related co-morbidities and their risk factors, based on multidisciplinary expert consultation, in a large HIV outpatient clinic and among an HIV-uninfected control group.1B) To assess the prevalence and…

A Phase III, multicenter, randomized, parallel-group, double blinded, placebo controlled study to evaluate the efficacy and safety of ocrelizumab in adults with Primary Progressive Multiple Sclerosis

Primary:To investigate the efficacy of ocrelizumab compared with placebo in patients with primary progressive multiple sclerosis, as measured by thetime to onset of confirmed disability progression over the treatment period, defined as an increase…

Phase II and Pharmacological Study with Wee-1 inhibitor AZD1775 Combined with Carboplatin in Patients with p53 Mutated Epithelial Ovarian Cancer that Show Early Relapse (<3 months) or Progression during Standard First Line Treatment with Carboplatin - Paclitaxel Combination Therapy. With an additional safety and preliminary anti-tumor activity cohort of Wee-1 inhibitor AZD1775 Combined with Carboplatin in Patients with p53 Mutated Epithelial Ovarian Cancer, non-small cell lung cancer (NSCLC), sm

Objective of the phase II POP study:To determine the safety and preliminary anti-tumor activity of AZD1775 in combination with carboplatin in p53 mutated epithelial ovarian cancer in a 21 day schedule.Objectives of the additional safety and…

Dose Reduction of preoperative radiotherapy in myxoid liposarcoma

To study the feasibility of reducing the dose of preoperative radiotherapy in MLS from 50Gy to 36Gy while maintaining comparable clinicopathological responses.

A randomized phase III study to compare Bortezomib, Melphalan, Prednisone (VMP) with High Dose Melphalan followed by Bortezomib, Lenalidomide, Dexamethasone (VRD) consolidation and Lenalidomide maintenance in patients with newly diagnosed multiple myeloma

*To assess the efficacy of VMP versus high-dose therapy (HDT) and stem cell transplantation in patients with previously untreated multiple myeloma, as measured by the progression free survival.**To evaluate the effect of consolidation with VRD…

Multicenter, randomized, double-blind, parallel-group extension to study AC 058B201 to investigate the long-term safety, tolerability, and efficacy of 10, 20, and 40 mg/day ponesimod, an oral S1P1 receptor agonist, in patients with relapsing-remitting multiple sclerosis

* To investigate the long-term safety and tolerability of ponesimod * To investigate the long-term efficacy of ponesimod* To explore the dose response relationship of 10, 20 and 40 mg ponesimod on lymphocyte count, MRI endpoints and annualized…

SUPREMO (Selective Use of Postoperative Radiotherapy AftEr
MastectOmy). A phase III randomised trial to assess the role of adjuvant chest wall irradiation in *intermediate risk* operable breast cancer following mastectomy.

Primary objective: To determine whether there is an overall survival benefit for patients with an intermediate risk breast cancer from chest wall irradiation following mastectomy, in addition to treatment with optimal modern systemic therapy.…

Open-label, multicenter study of the 18F labeled PET/CT (positron emission tomography / computed tomography) tracer BAY 86-9596 following a single intravenous administration of 200 or 300 MBq (corresponding to <= 18 µg mass dose), for evaluation of radiation dosimetry, plasma pharmacokinetics, safety and tolerability in healthy volunteers (200 MBq) as well as investigation of safety, tolerability and diagnostic performance in patients (300 MBq) with non small cell long cancer, breast cancer, hea

Primary objective:Explorative investigation of the tumor detection rate with BAY 86-9596 in comparison to that of 18F-fluorodeoxyglucose (FDG)Secondary objectives:- Determination of radiation dosimetry and pharmacokinetics of BAY 86-9596 in healthy…

Functional analysis of molecular mechanisms underlying parasympathetic regulation of human adipose

To characterize the molecular mechanisms underlying parasympathetic regulation of adipose tissue.

BIOTRONIKS-Safety and Clinical Performance of the First Drug-Eluting Generation Absorbable Metal Stent In Patients with de Novo Lesions in Native Coronary Arteries (BIOSOLVE-I study)

To evaluate safety and clinical performance of the investigation product (drug-eluting absorbable metal stent system)