3071 results
To confirm the safety of the Articulinx ICC by evaluating device- and procedure relates adverse events.
To determine the effectiveness and, subsequently, the cost-effectiveness of a endoscopic transluminal step-up approach (ETD & ETN) versus a surgical step-up approach (PCD & VARD ,if not possible laparotomy) to improve clinical…
Imaging disease activity in patients with Graves' orbitopathy using [18F]-FDG-PET/CT - a pilot study
To determine whether 18FGD-PET/CT imaging is able to show difference in [18F]-FDG uptake in orbital tissue between patients with active and inactive GO.
Phase 1: Investigate a possible suppressing effect of prophylactic paracetamol use in adults on the response of the hepatitis B vaccination. Phase 2: Study the association between timing of the use of paracetamol during hepatitis B vaccination and…
To assess the efficacy of an intervention directed towards prevention of clinical CF exacerbations by means of early recognition and early antibiotic treatment.
Determining VEGF expression in pHGG and DIPG using 89Zr-Bevacizumab
The aim of the present study is:a) to monitor the development of arm-hand use in a broad range of stroke patients over time both during and after clinical rehabilitation;b) to assess the rate of improvement (or decline) in arm-hand use during and…
The primary objective of this study is to examine the beneficial effects of nutritional support on the resistance type exercise training-induced changes in body composition and muscle fiber characteristics in healthy young men.
The primary objectives are to:• Compare progression-free survival (PFS) in patients with metastatic or locally advanced (unresectable) chondrosarcoma administered IPI-926 or placebo.• Evaluate the safety of IPI-926 in patients with metastatic or…
The primary objectives are:- To evaluate the efficacy of IV induction regimens of ustekinumab in inducing clinical response in subjects with moderately to severely active Crohn*s disease who have failed or are intolerant to one or more tumor…
* To investigate the effect of roflumilast 500 µg tablets once daily versus placebo on exacerbation rate, and pulmonary function and major adverse cardiovascular events (MACE) in COPD patients who are concomitantly treated with a fixed combination…
To identify which component of hemodialysis is primarily involved in the reduction in myocardial blood flow.
OBJECTIVE: Primary Objective:Among patients with symptomatic osteoarthritis of the knee(s) who are prescribed oral or topical analgesics for their symptoms, characterize over a 12-month follow-up period the clinical care and outcomes of patients who…
Inhibition of CYP2D6 enzymes by SSRIs may lead to reduced endoxifen plasma concentrations and thereby possibly influence tamoxifen treatment outcome. Paroxetine is a potent CYP2D6 inhibitor and strongly reduces endoxifen plasma concentrations.…
The first aim of this study is to determine the prevalence of cognitive impairment in COPD patients compared with persons without COPD and to compare cognitive functioning between patients referred by their general practitioner, patients referred by…
Primary objectiveDoes administration of THC produce an increase in subcortical dopamine level of chronic cannabis users? Does this effect on dopamine modulate the link between spontaneous eye blink rate, performance on divergent and convergent…
We would like to conduct a multicentre randomised controlled clinical trial to compare the difference in early postoperative pain after unilateral primary inguinal hernia repair in males. The procedures will be performed in day surgery. Early…
To investigate the real incidence of POAF a Reveal device is implanted. Afterwards a risk stratification of POAF is made.Using modern mapping equipment and techniques, it is now possible to investigate the substrate for development of atrial…
RO5458640 is an investigational therapy being studied by Hoffmann La Roche, Inc. and the Dutch Cancer Institute for treating solid tumor cancers. This study is looking for approximately 100 subjects with advanced solid tumors.
The overall goal of this RCT is to compare the efficacy of 90Y-RE to TACE-DEB, for patients with intermediate stage HCC. Time to progression, overall survival, tumor response, adverse events, treatment related effect on total liver function, quality…