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Effect of lung recruitment on haemodynamics in ventilated newborns

Monitoring the haemodynamic status during lung recruitment.

Diagnostic accuracy of Continuous Doppler Registration for early detection of hepatic artery thrombosis after liver transplantation

Determine feasibility and reliability of CDFM in relation to the current strategy of intermittent Doppler US examinations for detection of hepatic artery thrombosis.

Revision of the reference values for aerobic capacity in healthy Dutch boys and girls aged 4-13 years using the Bruce treadmill protocol.

Revision of the reference values for aerobic capacity in healthy Dutch boys and girls aged 4-13 years using the Bruce treadmill protocol.

Physical fitness of preterm children aged 6 and 7 years. The influence of daily fysical activity level and the attitude of parents on fysical fitness.

The first aim of this study is to obtain insight in the physical fitness of ex-preterms. The second aim is to study the influence of the daily activity pattern of the children on physical fitness. The third aim is to study the attitude of parents…

HERNIA-study:
congenital diaphragmatic Hernia, Environment, Retinoids, Nutrition, Inheritance, other Associations

- To analyze retinoid levels in plasma and amniotic fluid from infants and mothers to establish the potential link between retinoids and CDH. - To establish a registry of blood and tissue samples that will be valuable for future studies of the…

Tied to mommy*s womb?: the effects of prenatal maternal thyroid function and emotional complaints on infants*, toddlers* and preschoolers* self-regulation and socio-emotional adjustment; Part I

To gain insight in the relation between maternal thyroid function and maternal emotional complaints during pregnancy and the development of the child in relation to the self-regulation capacities of the child.

Alternative IntraOsseous Infusion
Randomised controlled trial comparing 3 intraosseous methods

Both in emergency departments and in prehospital services (ambulances and MMTs) effort is being done to find a fast alternative for the screw-tipped bone needle that has the least amount of risk and complications.The aim of this study is to analyse…

Explorative research for the maturation of sucking patterns in preterm infants; follow-up research for the relation with the outcome at tha age of 27 and 48 months with regard to language and mental development.

Also in the group of *healthy prematures*, many children appear to have a deviant sucking pattern op de a terme leeftijd. We want to know the implications of these deviant findings for the later development of the children in question.Only recently…

Defecation characteristics of the preterm and term neonate during the first years of life

What is the normal stool frequency among premature and full term neonates?What is the normal colour of stools of the neonate?What is the normal consistency and amount of stools?What is the normal colonic transit time of premature and full term born…

Neonatal C-peptide concentration in urine: is it related to birthweight and glucose values on the first day of life or parameters of carbohydrate metabolism in non-diabetic mothers

to determine the correlation of fetal hyperinsulinemia (measured by urine c-peptide) and maternal indicators of glucose-regulation with neonatal birth weight and postpartum glucose concentration of macrosomic infants of non-diabetic mothers

Child and Trauma I: Prevalence of trauma and posttraumatic reactions in elementary school children.

Central research questions in this study are:1) To what extent are elementary school children exposed to traumatic events?2) What type events did these children experience (e.g. accidents, acts of violence, severe disease, death of a loved one)? 3)…

Efficacy of Inhaled RhDNase in Mechanically Ventilated Pediatric Patients with an Atelectasis

To evaluate the efficacy of inhaled rhDNase in addition to conventional treatment in children with an atelectasis during mechanical ventilation.

Propiverine hydrochloride in children suffering from overactive bladder and urinary incontinence. A randomised, double-blind, placebo-controlled, parallel grouped multicentre clinical trial

This study is designed to demonstrate superiority of efficacy of Propiverine hydrochloride compared to placebo in children suffering from overactive bladder with urinary incontinence.The primary objective is to compare efficacy of Propiverine…

Effect of Botulinum Toxin A Injections and Specific Intensive Rehabilitation Therapy in Children with Hemiparetic Cerebral Palsy on Upper Limb Functions and Skills

Objective: to determine whether botulinum toxin A (btA) injections, intensive bimanual skill training, or a combination of both leads to more and better use of the affected arm in hemiparetic children in play, leisure time, school and personal care.

Objective measurement of behavioural parameters of pain in infants

To test the feasibility and added value of facial electromyography to continuous pain monitoring in infants

Executive control functions in autism spectrum disorders

The primary objective of this study is to specify the executive control processes that contribute to mental inflexibility in persons with autism. The specific part of mental flexibility we are interested in includes processes involved in task…

Leiden's IVIg trial in Rhesus disease of the Neonate

AimTo determine whether the prophylactic use of IVIg reduces the need for ET in neonates with Rh-D hemolytic disease.

Ethanol lock solution for the prevention of tunnelled central venous catheter infections in paediatric oncology patients
A randomized controlled trial

To prove the efficacy and safety of ethanol lock solution in preventing catheter-related infections and subsequently venous thrombosis in children with a malignant disease who will have a tunnelled central venous catheter inserted.

Sensory specific satiety and flavour intensity - Differential effects in children and adults

To determine the differential effect of age (children vs. adults) on the development of sensory specific satiety (SSS) in relation to intensity of drinks (both sweetness and flavour). To compare two methods of assessing SSS.

Continuous EEG registration and surveillance at the NICU in neonates with hypoxic-ischemic encephalopathy

Is continuous EEG registration with a 9 and 21 channel EEG with SL detection an approved method for the detection of seizures in term neonates with perinatal hypoxia-ischemia? What are the sensitivity and the false positive rate of these methods in…