360 results
Objective:The aim of our study is to obtain a collection of head and neck squamous cell carcinomas that is well characterized for relevant clinical parameters, including follow-up.
Primary Objective: To gain more insight in the genetic susceptibility for AIH. For this we will study the presence of candidate genes in AIH patients, study genetic similarities with other auto-immune diseases and perform a whole genome association…
Validation of CT angiography and MRI protocols to identify the different components of the atherosclerotic plaque in the carotid arteries compared to and histology.
To demonstrate whether using MSCT to reclassify individuals who are at high-risk based on traditional risk factors.
To design a multivariate prediction model of pregnancy outcome in women with PCOS with the intention to define intervention strategies for the future.
The aim of the current study is to:1. Determine the incidence of CIN after introduction of preventive measures.2. Describe changes in the course of biomarkers serum creatinine, microalbumin and microglobulin related to intravenous ICM administration…
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
The primary objective of the study is to determine whether the optimal atrioventricular delay and interventricular delay in cardiac resynchronization therapy are a function of exercise. Secondary objectives are the development of an automatic…
To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis
To determine the toxicity of Zirconium-89 (Zr89) labelled Cetuximab in patient with stage IV cancer.
This study will be conducted in two parts as described below:Part 1 will include subjects who participated in a Phase 1, 2, or 3 clinical study in which boceprevir was administered.Part 2 will include subjects who participated in a Phase 1, 2, or 3…
Compare clinical investigation with different high-resolution MR imaging protocols in the preoperative assessment of patients with vulva carcinoma.
Given that previous studies demonstrated the feasibility of the required MRI techniques, we propose to studythe macro- and microvascular adaptations in PAOD patients undergoing supervised exercise therapy. It isexpected to provide valuable insights…
The objectives of this study are to gain new insights on [1] the cause of a higher clopidogrel resistance in DMII patients[2] the increased production of tissue factor in monocytes in DMII patients
Within WP6 of a EU Seventh Framework project, we will investigate associations between purinergic receptor SNPs and osteoporosis risk in humans. Genetic data from a fracture cohort in The Netherlands with high prevalence of osteoporosis will be…
The objective of this study is to determine the accuracy of the sentinel lymph node biopsy in multicentric breast cancer prospectively and multi-institutional.
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To predict the risk of particular coronary plaques to cause myocardial infarction
Aims: 1. To optimize the diagnosis of M. pneumoniae infections by discriminating between colonization and symptomatic infection using quantitative PCR. 2. To study the role of host factors (age, and bacterial and viral co-infection) on infection by…
In this research project, we will investigate the feasibility of multi-unit microneurography for the research of human muscle mechanoreceptors. We will therefore answer the following questions:1) How hard is it to find and maintain an effective…