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Thermal stability of Pyruvate kinase In Red blood cells

Main objective: - To investigate pyruvate kinase thermal stability in haemoglobinopathies.Secondary objectives: - To investigate the possibility of stimulation of PK activity and thermal stability by use of allosteric activators- To investigate…

Near-Infrared fluorescence imaging in open and laparoscopic hepatectomy: improving safety of the extra-glissionian approach?

The main objective of this trial is to investigate the ability to visualize the exact location of left and right confluence of the bile ducts and thereby distinct between right and left hepatic ducts and the common hepatic duct using NIRF imaging.…

Long-term hepatotoxicity of azathioprine, 6-mercaptopurine and 6-thioguanine in IBD patients

Assess hepatotoxicity of long-term azathioprine and 6-mercaptopurine use in IBD-patients as compared with a cohort of long-term 6TG users

The Dutch Injection versus Surgery TRIal in Carpal Tunnel Syndrome patients

The objective of this study is to assess the efficacy and cost-effectiveness of a treatment strategy starting with surgical intervention compared to a starting treatment with steroid injection.

STEP:
Study of Tumor Educated Platelets for early detection of breast cancer in blood in BRCA1/2 mutation carriers

- To study sensitivity and specificity of the MeD-seq test for detection of BrCa in female BRCA1/2 mutation carriers in an early stage.- To determine if the MeD-seq test can detect BrCa earlier in time than current surveillance tools (MRI/…

A PHASE I, SPONSOR-OPEN, INVESTIGATORBLINDED,SUBJECT-BLINDED, MULTI-CENTER,
PLACEBO-CONTROLLED STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETICS
AND PHARMACODYNAMICS OF ORAL ADMINISTRATION OF RO7020531: (1). SINGLE
AND MULTIPLE ASCENDING DOSES IN HEALTHY MALE AND FEMALE SUBJECTS; (2). 6-WEEK
TREATMENT OF VIROLOGICALLY SUPPRESSED PATIENTS WITH CHRONIC HEPATITIS B VIRUS
INFECTION

OBJECTIVESPrimary ObjectivesThe primary objective is:* To assess the safety and tolerability of 6 weeks of treatment with RO7020531 administered orally to virologically suppressed chronic hepatitis B (CHB) patients.Secondary ObjectivesThe secondary…

Prospective follow-up of clinical efficacy of knee distraction as treatment for knee OA by use of 'ArthroSave's Knee-Reviver'.

To document clinical efficacy of ArthroSave*s Knee-Reviver at 1, 2 and 5 years after distraction by:1st: an increase in WOMAC score (pre-treatment vs. follow-up).2nd: an increase in radiographic joint space width (pre-treatment vs. follow-up)

Physical Activity and Dietary intervention in OVArian cancer (PADOVA): a RCT evaluating effects on body composition, physical function, and fatigue

This single blind randomized controlled trial evaluates the effects of a combined supervised exercise and dietary intervention during chemotherapy treatment on body composition, physical function and fatigue (primary outcomes). Secondary outcomes…

The occurence of cam impingement in young male soccer players.

We want to investigate the hip joints of young very active male soccer players to gain greater knowledge on the development of cam impingement, concerning the shape deformities, the age of onset and the occurrence of cartilage lesions.

Phase 1b, multi-arm, open-label study of PDR001 and/or MBG453 in combination with decitabine in patients with acute myeloid leukemia or high risk myelodysplastic syndrome (CPDR001X2105)

Primary: To characterize the safety and tolerability of PDR001 and/or MBG453 in combination with decitabine or azacitidine in relapsed/refractory AML patients, de novo AML patients not candidates for standard induction therapy, or high risk or…

*MRI protocol development for MR-linac*

To optimize MRI protocols and processing techniques required for MRI guided radiotherapy on the MR-linac measured as signal to noise ratio, contrast, and acquisition time.

Pulmonary artERial hypertenSion: bonE morPHOgeNEtic protein signaling out of control (PERSEPHONE)

Assess BMP10 secretion in patients with pulmonary arterial hypertension and its effect on right ventricular adaptation to pressure overload.

The noradrenergic basis of Parkinson*s tremor: a systems-level fMRI approach

I will test the hypothesis that the noradrenergic system amplifies tremulous activity in the cerebello-thalamo-cortical circuit. More specifically, I will test how this modulation takes place (i.e. through which brain regions and connections).

Risk-stratified randomized controlled trial in paediatric Crohn*s Disease: Methotrexate versus azathioprine or adalimumab for maintaining remission in patients at low or at high risk for aggressive disease course, respectively * a treatment strategy

To compare the effectiveness of weekly subcutaneously administered MTX for maintaining relapse-free sustained steroid/EN-free 1-year remission compared with:- daily oral AZA/6MP in low risk paediatric CD- subcutaneously administered adalimumab in…

SHERLOCk: An integrative genomic approach to Solve tHe puzzle of sevERe (earLy-Onset) COPD

The aim of this study is to identify why a subset of COPD patients develops such a severe COPD at early age and with relatively few packyears smoking. This will need a functional genomics approach integrating both whole genome DNA sequencing data in…

A NOVEL observational longiTudinal studY on patients with a diagnosis or
suspected diagnosis of asthma and/or COPD to describe patient
characteristics, treatment patterns and the burden of illness over time and
to identify phenotypes and endotypes associated with differential outcomes
that may support future development of personalised treatment strategies

The primary objectives are:*To describe patient characteristics, treatment patterns and the burden of illness over time for individuals in clinical practice with a diagnosis, or suspected diagnosis,2of asthma and/or COPD. Data will be described for…

A Randomized, Double-blind, Placebo-controlled, Adaptive Study to Evaluate Symptom Improvement and Metabolic Control Among Adult Subjects With Symptomatic Hypoparathyroidism Treated With Recombinant Human Parathyroid Hormone [rhPTH(1-84)]

The primary objective is to test the hypothesis that rhPTH(1-84) treatment can result in superior improvements in the symptoms of hypoparathyroidism as assessed by the Hypoparathyroidism Symptom Diary (HPT-SD) symptom subscale compared with standard…

The effect of a gastric bypass on the pharmacokinetics of citalopram

Primary objective: Determine whether a RYGB operation causes a clinically significant decrease in AUC (area under serum concentration-time curve) of citalopram three months after surgery in comparison with the situation before the operation.…

Pharmacogenetics Use For Further treatment Improvement in childreN

To assess whether ADRB2 genotype-guided asthma treatment in children with persistend athma symptoms despite ICS treatment leads to better asthma control compared to non-genotype-guided asthma treatment.

A Phase 3, Randomized, Double-Blind, Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Subjects with Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug (DMARD) - SELECT - PsA 1

This is a Phase 3 multicenter study that includes two periods. Period 1 is designed to compare the safety, tolerability, and efficacy of upadacitinib low dose once daily (QD) and high dose B QD versus placebo and versus adalimumab every other week (…