154 results
Objectives: The aim of this study is to:I Identify pathogenic mutations in novel genes, causing PCDII Develop a diagnostic PCD test, based on MPSIII Validate MPS technique for PCD.
1: Elucidation of the factors that cause the complement deficiency in pediatric oncology patients. First, we will characterize the inhibitor of MASP-2 activity in patients during chemotherapy. 2: Identification of the complement component(s) causing…
This project aims at investigating the differences between number and fenotype of T cells involved in GvHD when comparing:a) gendermatches: gender-mismatched (female donor, male patient) versus gender-matched (other combinations);b) stem-cell source…
The main objective is to determine whether medication-free adolescents with ADHD show impairments in affective and complex social cognition. The secondary objectives are: 1) To determine whether the use of stimulant medication (on and off) affects…
To enhance the (functional) communicative skills of children/adolescents with severe communicative problems with the use of specialized AAC aids in order to optimize their participation at home, in school and other social contexts.
The main objective of this study is to characterize the flow of information in the fronto-parietal network during the simulation of movements using intracranial EEG recordings. In the characterization we will pinpoint the neuronal (sub)regions of…
In this study, three main hypotheses are tested. The first hypothesis focuses on the expectation that an intervention aimed at training cognitive components of social competence affect the level of social competence and well-being of adolescents…
The aims of our study are:1. To use electronic nose measurements to discriminate between well-defined groups of children with different levels of asthma control. 2. To use electronic nose measurements to distinguish between different levels of FeNO…
Primary objective:- To obtain reference values for arterial stiffness, measured as PWV and AIx, and insulin resistance, calculated as HOMA-IR in normal weight, healthy adolescents in different Tanner stages.Secondary objectives: - To determine the…
Is it possible to make a discrimination in muscle activity between the right and left puborectalis muscle by using concentric needle electrodes in an electromyography investigation of the pelvic floor muscles?When a asymmetry is found, what can be…
The aim of this study is to investigate, by direct comparison, which of 3 treatment strategies is the most effective and safe. The treatment goal in all strategy arms will be inactive disease. When inactive disease is achieved according (to the…
The primary objective of this study is to test the hypothesis that risperidone given orally in a dose of 0.25 - 3.0 mg/d depending on body weight (eq. to approximately 0.01 - 0.04 mg/kg/d) for 12 weeks is superior to placebo in reducing disruptive…
This study tries to operationialize the construct of resiliency in young refugees and studies its significance in coping with the sometimes very serious consequences of war and migration from a psychological overarching framework. The project aims…
The primary objective is to test the hypothesis that, after at least 15 weeks of daily administration (4 for titration, 7 of relatively stable dose, 4 at fixed doses; Study Period II), risperidone given orally in a dose of 0.25 - 3.0 mg/d depending…
To examine if trauma exposed adolescents (who are developing their identity) who met the diagnostic criteria for PTSD, compared with trauma exposed adolescents who don*t met those criteria, show a stronger implicit association between the self and…
In the present study the prevalence of and risk factors for vitamin D deficiency will be determined in a patient population with a fracture in the upper or lower extremity.
Primary Objectives:1: Gain insight in the way arm function changes during the natural course of DMD through 3D movement analysis, surface electromyography and ambulant activity monitoring.2: Investigate if a newly developed exoskeleton is able to…
To evaluate the effect of additional foot support during sitting and the effect of forward tilting of the seat surface on 1) postural adjustments during reaching and 2) the quality of reaching movement in school age children with CP.
The main objective of this proposal is to request permission for recruitment and participation of individuals between ages 8 and 30 in an fMRI session and several behavioral testing sessions. These studies are aimed at relating brain development to…
In patients long-term after AVSD correction the objectives are:1) To evaluate myocardial function using novel echocardiographic techniques.2) To study atrial en ventricular size and function in relation to quantification of AVV function with the use…