4232 results
The primary objective of the study is Study to determine the Safety, Tolerability, Pharmacokinetics and Effect on Circulating Alpha-1 Antitrypsin Levels of ARC-AAT in Patients with Alpha-1 Antitrypsin Deficiency (AATD)
To evaluate whether integral AF treatment in primary care is non-inferior in terms of reducing all-cause mortality (primary outcome) and specific cardiac mortality and hospitalization and non-cardiac hospitalization (secondary outcomes), as compared…
- To evaluate the bladder-preservation rate after chemoradiation - To evaluate the toxicity and complications of treatment with induction chemotherapy followed by ePLND and chemoradiation
The primary objective of the study is as follows:· To compare the rate of asthma exacerbations between patients with low baseline periostin levels (< 50 ng/mL) and patients with high baseline periostin levels (* 50 ng/mL), as measured by…
The primary objective of the proposed study is to examine the neural substrate of cognitive and social-emotional apathy in patients with schizophrenia. Secondary, we intend to explore the concentration of brain metabolites and structural differences…
The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…
In this study, we explore the correlation between baseline intratumoral CD8+ cell density and objective response rate (ORR) as well as other biomarker parameters in subjects with unresected stage IIIB to IVM1c melanoma treated with talimogene…
Primary objectives: to investigate functional and histopathological changes of the right ventricle before and after PVR and PPVI. To investigate if non-invasive assessment of RV-remodeling using CMR T1 mapping and T1rho mapping is possible and to…
This study is designed in order to determine the type and timing of sexual rehabilitation after prostate cancer treatment according to the patient*s and the patient*s partner*s point of view. Furthermore, it will assess which health care provider…
To determine the effects, feasibility and costs of a multi-component cognitive behavioural intervention for reducing fear of falling and associated activity restriction in hip fracture patients admitted for geriatric rehabilitation.
To evaluate the effect of AMG 334 compared to placebo on the change from baseline in mean monthly migraine days, in subjects with episodic migraine.hypothesis: In subjects with episodic migraine, AMG 334 has a greater reduction from baseline in mean…
1) Main Objective: To investigate the validity, reliability and feasibility of the Clinician*s Rating Scale for evaluating impaired self-awareness and denial of disability after brain injury (CRS-ISA-DD) for use in the Dutch clinical practice.2)…
To validate spectral analysis of the fHRV as a new method for fetal monitoring. To determine the exact influence on fHRV of several commonly used medicines in obstetric care; namely tocolytic drugs, corticosteroids, antihypertensive agents,…
The objective of this protocol is to provide a mechanism to supply mepolizumab on an individual subject basis to eligible asthma subjects who previously participated in a GSK-sponsored mepolizumab study. During the execution of the protocol SAEs…
Primary Objective: To compare the effects of hypothyroidism and hyperthyroidism on cardiac left ventricular function, as assessed by CMR, in subjects with differentiated thyroid cancer during their early treatment.Secondary Objective(s): To compare…
to determine the percentage of patients with CKD, without a history of gout or attacks of arthritis, that have tophi measured by US,DECT and clinical examination. to determine the percentage of patients with CKD, that have tophi measured by US, and…
The primary objective of this study is to explore user acceptance of the HiM system in the usability study and to examine changes in functional use of the hand during ADL after prolonged use of a wearable robotic device by stroke patients in the…
The main objective of this study is to investigate the effect of a topically applied emollient enriched with barrier lipids on the barrier properties of skin of AE patients.
The current study is a continuation of the cohort 5-8 years post-diagnosis and aims to evaluate:1.The course of the nutritional status, and the related factors and consequences of malnutrition in survivors of childhood cancer until 5-8 years post-…
1. Immunology and Pathology:To determine the immune response of patients with simple and complex appendicitis in order to identify markers which distinguish between simple and complex appendicitis.2.Clinical and Imaging:To analyze the differences in…