3303 results
To demonstrate that percutaneous flexor tenotomy is an effective way to treat poorly healing ulcers in diabetic patients with hammertoes. We want to measure this effect by determining the healing time, percentage healed wounds and decrease in size…
Primary Objective: To study changes of T cell subsets (Th1/Tc1, Th2/Tc2, Th17/Tc17, regulatory T cells and senescent T cells) in healthy ageing and unhealthy ageing. Secondary Objective(s): - To study the immune risk phenotype in healthy persons…
We want to investigate wether a para-vertebral block contributes to a reduced postoperative pain and morphine consumption in patients with breast cancer after a unilateral mastectomy or lumpectomy. By doing this investigation we hope to clarify,…
To eveluate the effect of amount of time past after last aspirin intake on platelet activability
The primary aim of the proposed study is to investigate whether adjunctive treatment of negative self-image with a specific intervention module (i.e. COMET) has added value in the treatment of patients with BPD compared with MBT without such a…
•To characterize the natural history and progression of DMD to help inform the design of future studies•To capture biomarkers of safety and disease progression•To provide comparative data for the development of rare exons for which formal controlled…
We aim to increase patient compliance by extending the existing treatment protocol of (oral or intravesical) anticholinergics plus application of CIC with the addition of bladder pressure measurement performed at home during CIC plus access to an…
The aim of the present study is to increase our understanding of the cost effectivity and the pathophysiology underlying the beneficial effect of autologous SCT. We will investigate the immunological mechanisms involved in the (re)induction of…
This study investigates if the BeweegKuur Depressive Symptoms is more (cost-)effective in comparison with "watchful waiting". Complementary, success factors and barriers of the implementation of the BeweegKuur Depressive Symptoms in…
To demonstrate that food elimination therapy based on component-resolved diagnostics is an effective and acceptable treatment for EoO patients.
This study aims to determine whether early start of oral intake in patients that underwent an esophagectomy is feasible and safe.
To assess the analgesic efficacy, safety, and tolerability of once daily orally administered GRT6005 in a total of 3 fixed doses (i.e., 200 µg, 400 µg, and 600 µg GRT6005) compared to placebo in subjects with moderate to severe chronic LBP.
Primary: To compare the reduction in frequency of partial-onset seizures on each of two trough ranges of everolimus (3-7 ng/mL and 9-15 ng/mL) versus placebo in patients with TSC who are taking one to three AEDs. Key secondary: Ability to completely…
Determining the effect of long-term weight loss after bariatric surgery on:- striatal dopamine D2/3 receptor availability - behavioral parameters- plasma hormones, metabolites and peptides involved in appetite regulation, and glucose metabolism
This study aims to determine the following: * What is the nature and extent of relational and sexual problems of stroke patients and their partners. * What is the time course of the relational and sexual problems of stroke patients and their…
The two primary objectives are to test the hypothesis that (1) structural and functional abnormalities of the fronto-striatal circuits are related to the development of compulsive and impulsive behaviour in ASD and OCD; and that (2) the glutamate…
to develop a *two hit* in vivo autologous RBCs transfusion model in healthy male volunteers.
The main objective of this pilot study is twofold: 1) To investigate whether and to what extent raped adolescents experience symptoms of posttraumatic stress disorder at maximum 18 months of follow-up, measured by standardised questionnaires and…
To investigate the effect of a Dutch Can Do Training (CDT) on self-efficacy in people with Relapsing Remitting Multiple Sclerosis.
We study training effects in patients that receive training in the early CVA-phase (CVA < 6 weeks).Goals:1. Determination of the training effects in the early phase of stroke. 2. Determination of quality of life in trained CVA patients with…