Search for a trial

Do cerebral microbleeds in asymptomatic individuals reflect early CAA?
The Early Detection of Angiopathy (EDAN) Study

The general aim of this study is to implement validated markers for CAA in asymptomatic individuals with CMBs, to investigate whether presence of CMBs signifies early CAA.

Detecting Musculoskeletal Parameters by Magnetic Resonance Imaging for Biomechanical Models

The main aim of this study is to estimate internal joint loading and muscle activations during activities of daily living. Therefore, biomechanical models are used that can predict these internal parameters non-invasively. However, to make these…

Developmental changes in the neural correlates for artificial grammar learning

Primary Objective: The primary objective of this study is to understand to which degree the language system of pre-pubertal children is still plastic compared to adults and which brain areas are recruited by these groups when learning an artificial…

The sword of Damocles. Managing fear of cancer recurrence with the SWORD intervention study (Survivors' Worries of Recurrent Disease).

Cognitive behavior therapy (CBT) seems a promising intervention to reduce FCR. The SWORD study (Survivors* Worries of Recurrent Disease) will examine the efficacy and cost-effectiveness of individual CBT compared to treatment as usual (TAU) in…

A randomized trial to increase the efficiency of the prevention of contrast induced acute kidney injury.
The Compass trial

To study whether the existing eGFR cut-off levels for preventive hydration of < 45 ml/min or between 45-60 ml/min in combination of other comorbidity at risk of CIN can be safely lowered to an eGFR < 30 ml/min, regarsless of the…

Relationship between coagulation disturbances and microcirculation alterations and the development of multi-organ failure in sepsis

Investigate the incidence and severity of early coagulopathy in severe sepsis and septic shock patients and investigate the correlation between these coagulation disturbances and the incidence and severity of microvascular changes.

Exercise-induced pulmonary hypertension in fibrotic idiopathic interstitial pneumonias. Correlations with cardiopulmonary exercise testing

The primary aim of this observational study is to determine the occurrence of (exercise-induced) pulmonary hypertension (sPAP > 40 mmHg) in IIP patients with an elevated V*E/V*CO2 at AT (> 34) assessed during CPET. And, secondly to…

effect of the combination of green lipped mussel, curcumin and ribus nigrum (supplement Synofit) on quality of life and pain in patients with osteoarthritis of the knee

measuring the efficicy of the combination of green lipped mussel, curcumin and ribus nigrum (supplement Synofit) on quality of life and pain in patients with osteoarthritis of the knee

Understanding others* mind: An investigation of the impact of virtual lesions to the ventral premotor cortex and the temporo-parietal junction

We want to demonstrate that inferring the state of mind of someone else on the basis of his/her actions requires the integrity of both the ventral premotor cortex (which is part of the mirror neuron system involved in motor simulation), and the…

Development of Tools (and prediction rules) to time and select therapy in treatment of pre-clinical, early and established Rheumatoid Arthritis: Creating Enhanced Remedy (TRACER): early rheumatoid arthritis

to combine and validate diagnostic and prognostic tests for patients with recently diagnosed rheumatoid arthritis to predict joint damage and response to (DMARD) therapy.

Complete endosonographic staging of lung cancer: a systematic single scope approach.

Complete endosonographic (combined endobronchial and esophageal) staging using a single EBUS scope improves locoregional staging (N2, N3, T4) versus EBUS (endobronchial) staging alone.

Nasal Potential Difference in suspected CF patients with 5T polymorphism * Comparison between patients from Israel and Netherlands

Clarify the effect of 5T polymorphism with or without another CF causing mutation on the other allele, on the CFTR function.

A prospective randomised controlled multicentre trial comparing half-dose photodynamic therapy (PDT) with high-density subthreshold micropulse laser treatment in patients with chronic central serous chorioretinopathy (CSC).

Primary ObjectiveTo investigate whether half-dose PDT treatment leads to a higher percentage of chronic CSC patients with subretinal fluid on OCT achieving an absence of this subretinal fluid on OCT as compared to HSML treatment.Secondary…

A randomised, multicentre, double-blind, placebo-controlled, crossover trial determining the efficacy of dry powder mannitol in improving lung function in subject with Cystic Fibrosis aged six to seventeen years.

The purpose of this trial is primarily to assess the efficacy of inhaled mannitol compared with a true placebo in subjects with cystic fibrosis aged 6 to 17 years.We hypothesize that inhaled mannitol will improve the overall health and hygiene of…

A study of more time-efficient and cost-effective pre-exposure rabies vaccination schedules to secure timely adequate protection prior to military deployment

1. To reduce the time required for pre-exposure rabies vaccination of military personnel2. To reduce costs of pre-exposure rabies vaccination of military personnel 3. To obtain a non-inferior immune response to a shortened, low-dosed scheme compared…

Fast-track thyroidectomy and radioiodine ablation therapy in patients with differentiated thyroid cancer.

This study aims to detect differences in sick leave time, associated costs and quality of life between differentiated thyroid cancer patients treated in either a fast-track protocol or a traditional longer time interval between total thyroidectomy…

Identification and characterization of community-dwelling older people with sarcopenia.

The objective of this study is to obtain insight in the characteristics of sarcopenic versus non-sarcopenic community-dwelling older people.

Clinical trial with Sarabesin 3, a GRP receptor antagonist, labelled with gallium-68, in patients with prostate cancer confined to the primary organ

In this proposed study, we aim to test not only the safety and biodistribution of [68Ga]Sarabesin 3, but also its potential to visualise prostate cancer. If the peptide proves to be successful, a next study will be initiated to test the potential to…

Enable® Aortic Sutureless bioprosthesis Evaluation (EASE study): A post-market release non-interventional study

The objective is to collect additional data on the clinical outcomes (surgical data, safety and clinical performance) of the Medtronic Enable® Aortic Bioprosthesis in *real world* patients. The collected data will be used to improve aortic valve…

intErNationaL non-randomized, sIngle arm, lonG-term follow-up study of patients with uncontrolled HyperTensioN (ENLIGHTN II)

The purpose of this Clinical investigation is to further evaluate the safety and performance of the EnligHTN* Renal Denervation System in the treatment of patients with uncontrolled hypertension.